Research workbench
Crystal structure of RGS7-GBETA5 dimer
Analyse Crystal structure of RGS7-GBETA5 dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N9G
- Type
- protein
- Length
- 1,504 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of G-protein signaling 7; Guanine nucleotide-binding protein subunit beta-5
- UniProt
- O46470, P62881
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of G-protein signaling 7 | protein | 400 | 59% helix, 5% strand | O46470 |
| B | Regulator of G-protein signaling 7 | protein | 401 | 59% helix, 3% strand | O46470 |
| C | Guanine nucleotide-binding protein subunit beta-5 | protein | 351 | 10% helix, 45% strand | P62881 |
| D | Guanine nucleotide-binding protein subunit beta-5 | protein | 352 | 10% helix, 45% strand | P62881 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1066 | 0.87 | 0.88 | 104 | empty |
| 2 | 1073 | 0.87 | 0.88 | 113 | empty |
| 3 | 260 | 0.65 | 0.82 | 33 | empty |
| 4 | 222 | 0.56 | 0.79 | 34 | empty |
| 5 | 100 | 0.55 | 0.85 | 29 | empty |
Interfaces
5 interfaces between chains.
- B–C · 4330 Ų buried · 40 hydrogen bonds · protein-protein
- A–D · 4264 Ų buried · 47 hydrogen bonds · protein-protein
- A–C · 635 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 561 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 23 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6N9G · Crystal Structure of RGS7-Gbeta5 dimer · the same entry in another collection · chain D against D, TM-score 1.00
- P62881 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein subunit beta-5… · a predicted model of the same protein · chain D against A, TM-score 0.94
- O46470 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 7 (O46470) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O46470
- Every structure of UniProt P62881
- Elsewhere: RCSB PDB 6N9G · PDBe 6N9G · UniProt O46470 · UniProt P62881
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