Research workbench
Cryo-EM structure of the importin BETA:HISTONE H1.0 complex
Analyse Cryo-EM structure of the importin BETA:HISTONE H1.0 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N89
- Type
- protein
- Length
- 947 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-1; Histone H1.0
- UniProt
- Q14974, P07305
- Pockets
- 2 · best druggability 0.52
Structure
electron microscopy · 2 distinct chains · 64% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-1 | protein | 873 | 66% helix, 0% strand | Q14974 |
| B | Histone H1.0 | protein | 74 | 46% helix, 19% strand | P07305 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.52 | 0.73 | 54 | empty |
| 2 | 164 | 0.37 | 0.72 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 62 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6N89 · Cryo-EM structure of the Importin beta:Histone H1.0 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P07305 · AlphaFold monomer V2.0 prediction for histone H1.0 (P07305) · a predicted model of the same protein · chain B against A, TM-score 0.75
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt P07305
- Elsewhere: RCSB PDB 6N89 · PDBe 6N89 · UniProt Q14974 · UniProt P07305
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