Cryo-EM structure of phosphodiesterase 6

Structure

electron microscopy · 4 distinct chains.

Ligands and binding sites

• 35G · Guanosine-3',5'-monophosphate · ligand · 2 copies · chains B, A
• ZN · Zinc ion · metal · 2 copies · chains B, A
• MG · Magnesium ion · metal · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6MZB · Cryo-EM structure of phosphodiesterase 6 · the same entry in another collection · chain D against D, TM-score 1.00
• P23439 · AlphaFold monomer V2.0 prediction for rod cgmp-specific 3',5'-cyclic phosphodiesterase… · a predicted model of the same protein · chain B against A, TM-score 0.97
• P11541 · AlphaFold monomer V2.0 prediction for rod cgmp-specific 3',5'-cyclic phosphodiesterase… · a predicted model of the same protein · chain A against A, TM-score 0.96
• P04972 · AlphaFold monomer V2.0 prediction for retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic… · a predicted model of the same protein · chain D against A, TM-score 0.24

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P23439
• Every structure of UniProt P11541
• Every structure of UniProt P04972
• Elsewhere: RCSB PDB 6MZB · PDBe 6MZB · UniProt P23439 · UniProt P11541 · UniProt P04972