UniProt P04972
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (P04972)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (UniProt P04972), EC 3.1.4.35: 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 42 pockets. Binding sites…
- UniProt
- P04972
- Protein
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit…
- EC
- 3.1.4.35
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 42 · 5 records with a druggable one
Structures
16 records of P04972 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FQJ | Crystal structure of the heterotrimeric complex of the rgs domain of RGS9, the gamma subunit of… | x-ray diffraction | C | — | — |
| 1FQJ | Crystal structure of the heterotrimeric complex of the rgs domain of RGS9, the gamma subunit of… | x-ray diffraction | C | — | — |
| 2JU4 | NMR structure of the gamma subunit of cGMP phosphodiesterase | solution nmr | A | — | — |
| 2JU4 | NMR structure of the gamma subunit of cgmp phosphodiesterase | solution nmr | A | — | — |
| 3JAB | Domain organization and conformational plasticity of the G protein effector, PDE6 | electron microscopy | D, P | — | — |
| 3JAB | Domain organization and conformational plasticity of the G protein effector, PDE6 | electron microscopy | D, P | — | — |
| 3JBQ | Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6 | electron microscopy | D, X | — | — |
| 3JBQ | Domain organization and conformational plasticity of the G protein effector, PDE6 | electron microscopy | D, X | — | — |
| 6MZB | Cryo-EM structure of phosphodiesterase 6 | electron microscopy | C, D | — | — |
| 7JSN | Structure of the visual signaling complex between transducin and phosphodiesterase 6 | electron microscopy | C, D | — | — |
| 8UFI | Cryo-EM structure of bovine phosphodiesterase 6 | electron microscopy | C, D | — | 9 (best 0.83) |
| 8UGB | Cryo-EM structure of bovine phosphodiesterase 6 bound to udenafil | electron microscopy | C, D | — | 4 (best 0.78) |
| 8UGS | Cryo-EM structure of bovine phosphodiesterase 6 bound to cGMP | electron microscopy | C, D | PCG | 9 (best 0.83) |
| 8ULG | Cryo-EM structure of bovine phosphodiesterase 6 bound to IBMX | electron microscopy | C, D | — | 12 (best 0.84) |
| 9CXH | Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP | electron microscopy | D, C | 5GP | 8 (best 0.85) |
| P04972 | AlphaFold monomer V2.0 prediction for retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic… | predicted | A | — | — |
Ligands
Experiment against prediction
- 1FQJ chain C against the predicted model P04972: TM-score 0.39, RMSD 2.70 Å
- 1FQJ chain C against the predicted model P04972: TM-score 0.39, RMSD 2.70 Å
- 3JAB chain D against the predicted model P04972: TM-score 0.33, RMSD 1.76 Å
- 3JAB chain P against the predicted model P04972: TM-score 0.33, RMSD 1.76 Å
- 3JAB chain D against the predicted model P04972: TM-score 0.33, RMSD 1.76 Å
- 3JAB chain P against the predicted model P04972: TM-score 0.33, RMSD 1.76 Å
- 3JBQ chain D against the predicted model P04972: TM-score 0.30, RMSD 1.12 Å
- 3JBQ chain D against the predicted model P04972: TM-score 0.30, RMSD 1.12 Å
- 3JBQ chain X against the predicted model P04972: TM-score 0.28, RMSD 2.00 Å
- 3JBQ chain X against the predicted model P04972: TM-score 0.28, RMSD 2.00 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.