UniProt P11541
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (P11541)
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (UniProt P11541), EC 3.1.4.35: 7 experimental structures on GenesisL1, 7 ligands bound, 64 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P11541
- Protein
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- EC
- 3.1.4.35
- Experimental structures
- 7
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 64 · 4 records with a druggable one
Structures
7 records of P11541 in the MolNFT archive: 7 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6MZB | Cryo-EM structure of phosphodiesterase 6 | electron microscopy | A | ZN, MG, 35G | — |
| 7JSN | Structure of the visual signaling complex between transducin and phosphodiesterase 6 | electron microscopy | A | ZN, MG, VDN, 35G | — |
| 8UFI | Cryo-EM structure of bovine phosphodiesterase 6 | electron microscopy | A | PCG, ZN, MG | 16 (best 0.83) |
| 8UGB | Cryo-EM structure of bovine phosphodiesterase 6 bound to udenafil | electron microscopy | A | PCG, ZN, MG, ZUD | 15 (best 0.78) |
| 8UGS | Cryo-EM structure of bovine phosphodiesterase 6 bound to cGMP | electron microscopy | A | PCG, ZN, MG | 17 (best 0.83) |
| 8ULG | Cryo-EM structure of bovine phosphodiesterase 6 bound to IBMX | electron microscopy | A | PCG, MG, ZN, IBM | 16 (best 0.84) |
| P11541 | AlphaFold monomer V2.0 prediction for rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit… | — | — | — |
Ligands
- MG · Magnesium ion · in 6 records
- ZN · Zinc ion · in 6 records
- PCG · Cyclic guanosine monophosphate · in 4 records
- 35G · Guanosine-3',5'-monophosphate · in 2 records
- IBM · 3-isobutyl-1-methylxanthine · in 1 record
- VDN · 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one · in 1 record
- ZUD · Udenafil · in 1 record
Elsewhere
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