Research workbench
The structure of the plasmodium falciparum 20S proteasome.
Analyse The structure of the plasmodium falciparum 20S proteasome. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MUW
- Type
- protein
- Length
- 6,252 residues
- Chains
- 28
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 20S proteasome alpha-1 subunit; 20S proteasome alpha-2 subunit; 20S proteasome alpha-3…
- EC
- 3.4.25.1
- UniProt
- Q8IAR3, C6KST3, Q8IDG3, Q8IDG2, Q8IBI3, Q8IK90, O77396, Q8I0U7, Q8I6T3, Q8I261, Q8IKC9, Q8IJT1, C0H4E8, Q7K6A9
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 14 distinct chains · 31% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | 20S proteasome alpha-1 subunit (EC 3.4.25.1) | protein | 251 | 35% helix, 17% strand | Q8IAR3 |
| B, P | 20S proteasome alpha-2 subunit (EC 3.4.25.1) | protein | 229 | 31% helix, 23% strand | C6KST3 |
| C, Q | 20S proteasome alpha-3 subunit (EC 3.4.25.1) | protein | 241 | 34% helix, 17% strand | Q8IDG3 |
| D, R | 20S proteasome alpha-4 subunit (EC 3.4.25.1) | protein | 233 | 30% helix, 25% strand | Q8IDG2 |
| E, S | 20S proteasome alpha-5 subunit (EC 3.4.25.1) | protein | 243 | 30% helix, 16% strand | Q8IBI3 |
| F, T | 20S proteasome alpha-6 subunit (EC 3.4.25.1) | protein | 236 | 31% helix, 19% strand | Q8IK90 |
| G, U | 20S proteasome alpha-7 subunit (EC 3.4.25.1) | protein | 234 | 31% helix, 20% strand | O77396 |
| H, V | 20S proteasome beta-1 subunit (EC 3.4.25.1) | protein | 196 | 30% helix, 22% strand | Q8I0U7 |
| I, W | 20S proteasome beta-2 subunit (EC 3.4.25.1) | protein | 222 | 27% helix, 23% strand | Q8I6T3 |
| J, X | 20S proteasome beta-3 subunit (EC 3.4.25.1) | protein | 205 | 31% helix, 22% strand | Q8I261 |
| K, Y | 20S proteasome beta-4 subunit (EC 3.4.25.1) | protein | 195 | 31% helix, 26% strand | Q8IKC9 |
| L, Z | 20S proteasome beta-5 subunit (EC 3.4.25.1) | protein | 204 | 30% helix, 20% strand | Q8IJT1 |
| M, a | 20S proteasome beta-6 subunit (EC 3.4.25.1) | protein | 213 | 30% helix, 29% strand | C0H4E8 |
| N, b | 20S proteasome beta-7 subunit (EC 3.4.25.1) | protein | 224 | 28% helix, 25% strand | Q7K6A9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1110 | 0.84 | 0.85 | 133 | empty |
| 2 | 996 | 0.79 | 0.81 | 107 | empty |
| 3 | 446 | 0.78 | 0.86 | 60 | empty |
| 4 | 898 | 0.77 | 0.80 | 106 | empty |
| 5 | 316 | 0.77 | 0.88 | 39 | empty |
Interfaces
86 interfaces between chains.
- A–G · 1775 Ų buried · 14 hydrogen bonds · protein-protein
- O–U · 1757 Ų buried · 13 hydrogen bonds · protein-protein
- X–W · 1626 Ų buried · 11 hydrogen bonds · protein-protein
- I–J · 1624 Ų buried · 12 hydrogen bonds · protein-protein
- T–U · 1506 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 6MUW · The structure of the Plasmodium falciparum 20S proteasome. · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IAR3
- Every structure of UniProt C6KST3
- Every structure of UniProt Q8IDG3
- Every structure of UniProt Q8IDG2
- Every structure of UniProt Q8IBI3
- Every structure of UniProt Q8IK90
- Every structure of UniProt O77396
- Every structure of UniProt Q8I0U7
- Every structure of UniProt Q8I6T3
- Every structure of UniProt Q8I261
- Every structure of UniProt Q8IKC9
- Every structure of UniProt Q8IJT1
- Every structure of UniProt C0H4E8
- Every structure of UniProt Q7K6A9
- Elsewhere: RCSB PDB 6MUW · PDBe 6MUW · UniProt Q8IAR3 · UniProt C6KST3 · UniProt Q8IDG3 · UniProt Q8IDG2 · UniProt Q8IBI3 · UniProt Q8IK90 · UniProt O77396 · UniProt Q8I0U7 · UniProt Q8I6T3 · UniProt Q8I261 · UniProt Q8IKC9 · UniProt Q8IJT1 · UniProt C0H4E8 · UniProt Q7K6A9
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