UniProt Q8IJT1
20S proteasome beta-5 subunit (Q8IJT1)
20S proteasome beta-5 subunit (UniProt Q8IJT1), EC 3.4.25.1: 14 experimental structures on GenesisL1, 4 ligands bound, 30 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8IJT1
- Protein
- 20S proteasome beta-5 subunit
- EC
- 3.4.25.1
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 30 · 6 records with a druggable one
Structures
14 records of Q8IJT1 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FMG | Structure and function based design of Plasmodium-selective proteasome inhibitors | electron microscopy | L, Z | — | 6 (best 0.77) |
| 5FMG | Structure and function based design of plasmodium-selective proteasome inhibitors | electron microscopy | L, Z | — | — |
| 6MUV | The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators | electron microscopy | L, Z | — | — |
| 6MUV | The structure of the plasmodium falciparum 20S proteasome in complex with two PA28 activators | electron microscopy | L, Z | — | — |
| 6MUW | The structure of the Plasmodium falciparum 20S proteasome. | electron microscopy | L, Z | — | 5 (best 0.75) |
| 6MUW | The structure of the plasmodium falciparum 20S proteasome. | electron microscopy | L, Z | — | — |
| 6MUX | The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator | electron microscopy | L, Z | — | 3 (best 0.78) |
| 6MUX | The structure of the plasmodium falciparum 20S proteasome in complex with one PA28 activator | electron microscopy | L, Z | — | — |
| 7LXT | Structure of Plasmodium falciparum 20S proteasome with bound bortezomib | electron microscopy | L, Z | BO2 | 6 (best 0.79) |
| 7LXT | Structure of plasmodium falciparum 20S proteasome with bound bortezomib | electron microscopy | L, Z | BO2 | — |
| 7LXU | Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 | electron microscopy | L, Z | YHD | — |
| 7LXU | Structure of plasmodium falciparum 20S proteasome with bound mpi-5 | electron microscopy | L, Z | YHD | — |
| 8G6F | Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor… | electron microscopy | L, Z | 7F1 | 6 (best 0.79) |
| 8W2F | Plasmodium falciparum 20S proteasome bound to an inhibitor | electron microscopy | L, Z | A1AE6 | 4 (best 0.79) |
Ligands
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 2 records
- YHD · N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide · in 2 records
- 7F1 · (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide · in 1 record
- A1AE6 · (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide · in 1 record
Elsewhere
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