Research workbench

Crystal structure of the KCTD12 H1 domain in complex with GBETA1GAMMA2 subunits

Analyse Crystal structure of the KCTD12 H1 domain in complex with GBETA1GAMMA2 subunits in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6M8S
Type: protein
Length: 2,458 residues
Chains: 15
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine…
UniProt: P62873, P59768, Q96CX2
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 10 distinct chains · 15% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	333	8% helix, 47% strand	P62873
G	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	334	8% helix, 46% strand	P62873
H, K	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	332	8% helix, 45% strand	P62873
I, J, E, F	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	55	65% helix, 0% strand	P59768
L	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	54	61% helix, 0% strand	P59768
A	BTB/POZ domain-containing protein KCTD12	protein	104	16% helix, 41% strand	Q96CX2
O	BTB/POZ domain-containing protein KCTD12	protein	105	19% helix, 44% strand	Q96CX2
P	BTB/POZ domain-containing protein KCTD12	protein	104	15% helix, 40% strand	Q96CX2
B	BTB/POZ domain-containing protein KCTD12	protein	101	17% helix, 44% strand	Q96CX2
M	BTB/POZ domain-containing protein KCTD12	protein	106	16% helix, 44% strand	Q96CX2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	831	0.85	0.88	103	empty
2	734	0.83	0.87	81	empty
3	450	0.82	0.90	64	empty
4	481	0.80	0.88	58	empty
5	354	0.80	0.89	48	empty

Interfaces

29 interfaces between chains.

C–E · 2261 Å² buried · 16 hydrogen bonds · protein-protein
G–I · 2241 Å² buried · 15 hydrogen bonds · protein-protein
D–F · 2218 Å² buried · 16 hydrogen bonds · protein-protein
H–J · 2212 Å² buried · 16 hydrogen bonds · protein-protein
K–L · 2091 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6M8S · Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits · the same entry in another collection · chain O against O, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62873
Every structure of UniProt P59768
Every structure of UniProt Q96CX2
Elsewhere: RCSB PDB 6M8S · PDBe 6M8S · UniProt P62873 · UniProt P59768 · UniProt Q96CX2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.