Research workbench
Structure of REV7-R124A complexed with SHLD3(37-73)
Analyse Structure of REV7-R124A complexed with SHLD3(37-73) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M7B
- Type
- protein
- Length
- 473 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; Shieldin complex subunit 3
- UniProt
- Q9UI95, Q6ZNX1
- Pockets
- 5 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 37% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 201 | 38% helix, 30% strand | Q9UI95 |
| B | Mitotic spindle assembly checkpoint protein MAD2B | protein | 200 | 38% helix, 30% strand | Q9UI95 |
| C, D | Shieldin complex subunit 3 | protein | 36 | 28% helix, 8% strand | Q6ZNX1 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 965 | 0.82 | 0.83 | 70 | empty |
| 2 | 200 | 0.57 | 0.80 | 24 | empty |
| 3 | 166 | 0.52 | 0.78 | 23 | empty |
| 4 | 66 | 0.48 | 0.84 | 23 | empty |
| 5 | 53 | 0.31 | 0.77 | 15 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1888 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 1820 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 721 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 370 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 298 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6M7B · Structure of REV7-R124A complexed with SHLD3(37-73) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q6ZNX1 · AlphaFold monomer V2.0 prediction for shieldin complex subunit 3 (Q6ZNX1) · a predicted model of the same protein · chain C against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI95
- Every structure of UniProt Q6ZNX1
- Elsewhere: RCSB PDB 6M7B · PDBe 6M7B · UniProt Q9UI95 · UniProt Q6ZNX1
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