Research workbench

Crystal structure of the N-terminal domain single mutant (D119A) of the human mitochondrial calcium uniporter fused with T4 lysozyme

Analyse Crystal structure of the N-terminal domain single mutant (D119A) of the human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KVX
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ENDOLYSIN,CALCIUM uniporter protein, mitochondrial
EC: 3.2.1.17
UniProt: D9IEF7, Q8NE86
Ligands: SO4
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ENDOLYSIN,CALCIUM uniporter protein, mitochondrial (EC 3.2.1.17)	protein	253	45% helix, 19% strand	D9IEF7, Q8NE86

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	381	0.59	0.76	46	SO4
2	73	0.43	0.81	19	empty
3	52	0.31	0.76	14	empty

Compared structures

6KVX · Crystal structure of the N-terminal domain single mutant (D119A) of the human… · the same entry in another collection · chain A against A, TM-score 1.00
Q8NE86 · AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q8NE86) · a predicted model of the same protein · chain A against A, TM-score 0.36

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D9IEF7
Every structure of UniProt Q8NE86
Elsewhere: RCSB PDB 6KVX · PDBe 6KVX · UniProt D9IEF7 · UniProt Q8NE86

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.