Research workbench
Crystal structure of STH1 bromodomain in complex with H3K14AC
Analyse Crystal structure of STH1 bromodomain in complex with H3K14AC in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KMJ
- Type
- protein
- Length
- 129 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear protein STH1/NPS1; Histone H3
- EC
- 3.6.4.12
- UniProt
- P32597, P61830
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear protein STH1/NPS1 (EC 3.6.4.12) | protein | 112 | 58% helix, 3% strand | P32597 |
| C | Histone H3 | protein | 17 | 24% helix, 6% strand | P61830 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–C · 841 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 6KMJ · Crystal structure of Sth1 bromodomain in complex with H3K14Ac · the same entry in another collection · chain A against A, TM-score 1.00
- P32597 · AlphaFold monomer V2.0 prediction for nuclear protein STH1/NPS1 (P32597) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P61830 · AlphaFold monomer V2.0 prediction for histone H3 (P61830) · a predicted model of the same protein · chain C against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32597
- Every structure of UniProt P61830
- Elsewhere: RCSB PDB 6KMJ · PDBe 6KMJ · UniProt P32597 · UniProt P61830
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