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Crystal structure of ca-bound human annexin A5 in low salt condition

Analyse Crystal structure of ca-bound human annexin A5 in low salt condition in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K22
Type: protein
Length: 316 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A5
UniProt: P08758
Ligands: CA
Pockets: 4 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A5	protein	316	69% helix, 0% strand	P08758

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.52	0.79	35	empty
2	102	0.45	0.79	19	empty
3	83	0.44	0.81	23	empty
4	96	0.42	0.78	13	empty

Compared structures

6K22 · Crystal structure of Ca-bound human Annexin A5 in low salt condition · the same entry in another collection · chain A against A, TM-score 1.00
P08758 · AlphaFold monomer V2.0 prediction for annexin A5 (P08758) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08758
Elsewhere: RCSB PDB 6K22 · PDBe 6K22 · UniProt P08758

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