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Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR

Analyse Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JPD
Type: protein
Length: 105 residues
Chains: 5
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-interacting SERINE/THREONINE-protein kinase 3
EC: 2.7.11.1
UniProt: Q9QZL0
Pockets: 1 · best druggability 0.28

Structure

solid-state nmr · 1 distinct chain · 0% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Receptor-interacting SERINE/THREONINE-protein kinase 3 (EC 2.7.11.1)	protein	21	0% helix, 29% strand	Q9QZL0

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.28	0.72	16	empty

Interfaces

4 interfaces between chains.

A–B · 890 Å² buried · 24 hydrogen bonds · protein-protein
C–D · 890 Å² buried · 24 hydrogen bonds · protein-protein
B–C · 890 Å² buried · 24 hydrogen bonds · protein-protein
D–E · 890 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

6JPD · Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR · the same entry in another collection · chain A against A, TM-score 1.00
Q9QZL0 · AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein… · a predicted model of the same protein · chain A against A, TM-score 0.19

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9QZL0
Elsewhere: RCSB PDB 6JPD · PDBe 6JPD · UniProt Q9QZL0

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