UniProt Q9QZL0
Receptor-interacting serine/threonine-protein kinase 3 (Q9QZL0)
Receptor-interacting serine/threonine-protein kinase 3 (UniProt Q9QZL0), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9QZL0
- Protein
- Receptor-interacting serine/threonine-protein kinase 3
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 2 records with a druggable one
Structures
9 records of Q9QZL0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4M66 | Crystal structure of the mouse RIP3 kinase domain | x-ray diffraction | A, B | — | — |
| 4M66 | Crystal structure of the mouse RIP3 kinase domain | x-ray diffraction | A, B | — | — |
| 4M69 | Crystal structure of the mouse RIP3-MLKL complex | x-ray diffraction | A | — | — |
| 4M69 | Crystal structure of the mouse RIP3-mlkl complex | x-ray diffraction | A | — | — |
| 6JPD | Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR | solid-state nmr | A, B, C, D, E | — | — |
| 6JPD | Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR | solid-state nmr | A, B, C, D, E | — | — |
| 6OKO | Crystal structure of mRIPK3 complexed with N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1… | x-ray diffraction | A, B | 1FN | 7 (best 0.80) |
| 6OKO | Crystal structure of MRIPK3 complexed with N-(3-fluoro-4-{1H… | x-ray diffraction | A, B | 1FN | — |
| Q9QZL0 | AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 3… | predicted | A | — | 3 (best 0.77) |
Ligands
- 1FN · 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide · in 2 records
Experiment against prediction
- 4M69 chain A against the predicted model Q9QZL0: TM-score 0.98, RMSD 0.92 Å
- 4M69 chain A against the predicted model Q9QZL0: TM-score 0.98, RMSD 0.92 Å
- 6OKO chain B against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.45 Å
- 6OKO chain B against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.45 Å
- 4M66 chain B against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.26 Å
- 4M66 chain B against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.26 Å
- 6OKO chain A against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.46 Å
- 6OKO chain A against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.46 Å
- 4M66 chain A against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.44 Å
- 4M66 chain A against the predicted model Q9QZL0: TM-score 0.96, RMSD 1.44 Å
Elsewhere
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