MolNFT v1 · #346075 · protein
AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 3 (Q9QZL0)
Q9QZL0: “AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 3 (Q9QZL0)”. 3 pockets (best druggability 0.77). MolNFT v1 #346075 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9QZL0
- Type
- protein
- Length
- 486 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3298b100681D3A2372Bba3b2f282750dD71629B9
- Molecule
- Receptor-interacting SERINE/THREONINE-protein kinase 3
- UniProt
- Q9QZL0
- Pockets
- 3 · best druggability 0.77
Structure
1 distinct chain · 28% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-interacting SERINE/THREONINE-protein kinase 3 | protein | 486 | 28% helix, 11% strand | Q9QZL0 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 951 | 0.77 | 0.80 | 88 | empty |
| 2 | 201 | 0.50 | 0.76 | 30 | empty |
| 3 | 65 | 0.42 | 0.81 | 18 | empty |
Compared structures
- 4M69 · Crystal structure of the mouse RIP3-mlkl complex · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 4M69 · Crystal structure of the mouse RIP3-MLKL complex · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 4M66 · Crystal structure of the mouse RIP3 kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.53
- 4M66 · Crystal structure of the mouse RIP3 kinase domain · an experimental structure of the same protein · chain A against A, TM-score 0.53
- 6OKO · Crystal structure of mRIPK3 complexed with N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy… · an experimental structure of the same protein · chain A against A, TM-score 0.53
- 6OKO · Crystal structure of MRIPK3 complexed with N-(3-fluoro-4-{1H… · an experimental structure of the same protein · chain A against A, TM-score 0.53
- 6JPD · Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR · an experimental structure of the same protein · chain A against A, TM-score 0.02
- 6JPD · Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR · an experimental structure of the same protein · chain A against A, TM-score 0.02
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QZL0
- Elsewhere: UniProt Q9QZL0 · AlphaFold DB Q9QZL0
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