Research workbench
Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10
Analyse Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JN2
- Type
- protein
- Length
- 134 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein af-10; Histone-lysine N-methyltransferase, H3 lysine-79 specific
- EC
- 2.1.1.43
- UniProt
- P55197, Q8TEK3
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein af-10 | protein | 67 | 87% helix, 0% strand | P55197 |
| B | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) | protein | 67 | 79% helix, 0% strand | Q8TEK3 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.46 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1322 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6JN2 · Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TEK3 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-79… · a predicted model of the same protein · chain B against A, TM-score 0.86
- P55197 · AlphaFold monomer V2.0 prediction for protein af-10 (P55197) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55197
- Every structure of UniProt Q8TEK3
- Elsewhere: RCSB PDB 6JN2 · PDBe 6JN2 · UniProt P55197 · UniProt Q8TEK3
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