Research workbench
EIF2A - EIF2B complex
Analyse EIF2A - EIF2B complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JLY
- Type
- protein
- Length
- 4,044 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor eif-2B subunit alpha; Probable translation initiation…
- UniProt
- Q9USP0, Q9UT76, P56288, Q09924, P56287, P20459
- Ligands
- PO4
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 11 distinct chains · 33% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor eif-2B subunit alpha | protein | 316 | 47% helix, 12% strand | Q9USP0 |
| B | Translation initiation factor eif-2B subunit alpha | protein | 316 | 46% helix, 13% strand | Q9USP0 |
| C | Probable translation initiation factor eif-2B subunit beta | protein | 338 | 51% helix, 14% strand | Q9UT76 |
| D | Probable translation initiation factor eif-2B subunit beta | protein | 337 | 51% helix, 14% strand | Q9UT76 |
| E | Probable translation initiation factor eif-2B subunit gamma | protein | 414 | 19% helix, 24% strand | P56288 |
| F | Probable translation initiation factor eif-2B subunit gamma | protein | 412 | 21% helix, 24% strand | P56288 |
| G, H | Probable translation initiation factor eif-2B subunit delta | protein | 363 | 43% helix, 12% strand | Q09924 |
| I | Probable translation initiation factor eif-2B subunit epsilon | protein | 428 | 20% helix, 25% strand | P56287 |
| J | Probable translation initiation factor eif-2B subunit epsilon | protein | 426 | 21% helix, 26% strand | P56287 |
| L | Eukaryotic translation initiation factor 2 subunit alpha | protein | 165 | 25% helix, 22% strand | P20459 |
| M | Eukaryotic translation initiation factor 2 subunit alpha | protein | 166 | 31% helix, 20% strand | P20459 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 8 copies · chains C, D, E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 545 | 0.85 | 0.91 | 81 | empty |
| 2 | 963 | 0.82 | 0.83 | 83 | empty |
| 3 | 349 | 0.79 | 0.89 | 60 | empty |
| 4 | 893 | 0.78 | 0.81 | 79 | empty |
| 5 | 767 | 0.78 | 0.82 | 74 | empty |
Interfaces
28 interfaces between chains.
- A–B · 3281 Ų buried · 33 hydrogen bonds · protein-protein
- D–H · 2365 Ų buried · 21 hydrogen bonds · protein-protein
- C–G · 2362 Ų buried · 20 hydrogen bonds · protein-protein
- D–J · 1499 Ų buried · 19 hydrogen bonds · protein-protein
- C–I · 1495 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6JLY · eIF2a - eIF2B complex · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9USP0
- Every structure of UniProt Q9UT76
- Every structure of UniProt P56288
- Every structure of UniProt Q09924
- Every structure of UniProt P56287
- Every structure of UniProt P20459
- Elsewhere: RCSB PDB 6JLY · PDBe 6JLY · UniProt Q9USP0 · UniProt Q9UT76 · UniProt P56288 · UniProt Q09924 · UniProt P56287 · UniProt P20459
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