UniProt P20459
Eukaryotic translation initiation factor 2 subunit alpha (P20459)
Eukaryotic translation initiation factor 2 subunit alpha (UniProt P20459): 25 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20459
- Protein
- Eukaryotic translation initiation factor 2 subunit alpha
- Experimental structures
- 25
- Predicted models
- 1
- Pockets
- 9 · 3 records with a druggable one
Structures
26 records of P20459 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q46 | crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia | x-ray diffraction | A | — | — |
| 1Q46 | Crystal structure of the EIF2 alpha subunit from saccharomyces cerevisia | x-ray diffraction | A | — | — |
| 2A19 | PKR kinase domain- eIF2alpha- AMP-PNP complex. | x-ray diffraction | A | — | — |
| 2A19 | Pkr kinase domain- EIF2ALPHA- AMP-pnp complex. | x-ray diffraction | A | — | — |
| 2A1A | PKR kinase domain-eIF2alpha Complex | x-ray diffraction | A | — | — |
| 2A1A | Pkr kinase domain-EIF2ALPHA complex | x-ray diffraction | A | — | — |
| 3J81 | CryoEM structure of a partial yeast 48S preinitiation complex | electron microscopy | j | — | — |
| 3J81 | Cryoem structure of a partial yeast 48S preinitiation complex | electron microscopy | j | — | — |
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | j | — | — |
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | j | — | — |
| 3JAQ | Structure of a partial yeast 48S preinitiation complex in open conformation | electron microscopy | j | — | — |
| 6GSM | Structure of a partial yeast 48S preinitiation complex in open conformation. | electron microscopy | j | — | — |
| 6I3M | EIF2B:EIF2 complex, phosphorylated on EIF2 alpha serine 52. | electron microscopy | K, L | — | — |
| 6I7T | EIF2B:EIF2 complex | electron microscopy | K, L | — | — |
| 6JLY | EIF2A - EIF2B complex | x-ray diffraction | L, M | — | — |
| 6JLZ | P-EIF2A - EIF2B complex | x-ray diffraction | L, M | — | — |
| 6QG0 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model 1) | electron microscopy | L, K | — | — |
| 6QG1 | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 2) | electron microscopy | L, K | — | 6 (best 0.84) |
| 6QG1 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model 2) | electron microscopy | L, K | — | — |
| 6QG2 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model a) | electron microscopy | K, L | — | — |
| 6QG3 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model B) | electron microscopy | K, L | — | — |
| 6QG5 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model C) | electron microscopy | K, L | — | — |
| 6QG6 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model D) | electron microscopy | K, L | — | — |
| 8QEL | PKR kinase domain- eIF2alpha in complex with compound | x-ray diffraction | A | — | 2 (best 0.77) |
| 8RW1 | Structure of a yeast 48S-AUC preinitiation complex in closed conformation | electron microscopy | j | — | 1 (best 0.89) |
| P20459 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2 subunit alpha… | predicted | A | — | — |
Experiment against prediction
- 8QEL chain A against the predicted model P20459: TM-score 0.98, RMSD 0.73 Å
- 1Q46 chain A against the predicted model P20459: TM-score 0.98, RMSD 0.82 Å
- 1Q46 chain A against the predicted model P20459: TM-score 0.98, RMSD 0.82 Å
- 2A19 chain A against the predicted model P20459: TM-score 0.97, RMSD 0.93 Å
- 2A19 chain A against the predicted model P20459: TM-score 0.97, RMSD 0.93 Å
- 2A1A chain A against the predicted model P20459: TM-score 0.97, RMSD 0.92 Å
- 2A1A chain A against the predicted model P20459: TM-score 0.97, RMSD 0.92 Å
- 6JLZ chain L against the predicted model P20459: TM-score 0.93, RMSD 1.46 Å
- 6JLZ chain M against the predicted model P20459: TM-score 0.93, RMSD 1.61 Å
- 6JLY chain M against the predicted model P20459: TM-score 0.92, RMSD 1.57 Å
Elsewhere
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