Research workbench
Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (17AA)
Analyse Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (17AA) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6J7A
- Type
- protein
- Length
- 1,621 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heme oxygenase 1,NADPH--cytochrome P450 reductase
- EC
- 1.14.14.18, 1.6.2.4
- UniProt
- P06762, P00388
- Ligands
- HEM, FAD, FMN
- Pockets
- 17 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heme oxygenase 1,NADPH--cytochrome P450 reductase (EC 1.14.14.18, 1.6.2.4) | protein | 814 | 45% helix, 15% strand | P06762, P00388 |
| B | Heme oxygenase 1,NADPH--cytochrome P450 reductase (EC 1.14.14.18, 1.6.2.4) | protein | 807 | 46% helix, 15% strand | P06762, P00388 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1130 | 0.80 | 0.81 | 105 | HEM, FMN |
| 2 | 477 | 0.77 | 0.84 | 45 | HEM |
| 3 | 617 | 0.72 | 0.80 | 59 | empty |
| 4 | 558 | 0.72 | 0.81 | 52 | empty |
| 5 | 578 | 0.70 | 0.79 | 81 | FAD |
Interfaces
1 interface between chains.
- A–B · 1475 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6J7A · Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (17aa) · the same entry in another collection · chain A against A, TM-score 1.00
- P00388 · AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388) · a predicted model of the same protein · chain A against A, TM-score 0.60
- P06762 · AlphaFold monomer V2.0 prediction for heme oxygenase 1 (P06762) · a predicted model of the same protein · chain B against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06762
- Every structure of UniProt P00388
- Elsewhere: RCSB PDB 6J7A · PDBe 6J7A · UniProt P06762 · UniProt P00388
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