UniProt P00388
NADPH--cytochrome P450 reductase (P00388)
NADPH--cytochrome P450 reductase (UniProt P00388), EC 1.14.14.18, 1.6.2.4: 47 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 98 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00388
- Protein
- NADPH--cytochrome P450 reductase
- EC
- 1.14.14.18, 1.6.2.4
- Experimental structures
- 47
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 98 · 8 records with a druggable one
Structures
48 records of P00388 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AMO | Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN-and… | x-ray diffraction | A, B | — | — |
| 1AMO | Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN-and… | x-ray diffraction | A, B | — | — |
| 1J9Z | CYPOR-W677G | x-ray diffraction | A, B | — | — |
| 1J9Z | CYPOR-W677G | x-ray diffraction | A, B | — | — |
| 1JA0 | CYPOR-W677X | x-ray diffraction | A, B | — | — |
| 1JA0 | CYPOR-W677X | x-ray diffraction | A, B | — | — |
| 1JA1 | CYPOR-Triple Mutant | x-ray diffraction | A, B | — | — |
| 1JA1 | Cypor-triple mutant | x-ray diffraction | A, B | — | — |
| 3ES9 | NADPH-Cytochrome P450 Reductase in an Open Conformation | x-ray diffraction | A, B, C | — | — |
| 3ES9 | NADPH-cytochrome P450 reductase in an open conformation | x-ray diffraction | A, B, C | — | — |
| 3OJW | Disulfide crosslinked cytochrome P450 reductase inactive | x-ray diffraction | A | — | — |
| 3OJW | Disulfide crosslinked cytochrome P450 reductase inactive | x-ray diffraction | A | — | — |
| 3OJX | Disulfide crosslinked cytochrome P450 reductase inactive | x-ray diffraction | A | — | — |
| 3OJX | Disulfide crosslinked cytochrome P450 reductase inactive | x-ray diffraction | A | — | — |
| 3WKT | Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1 | x-ray diffraction | A, B | — | — |
| 3WKT | Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1 | x-ray diffraction | A, B | — | — |
| 4Y7C | rat CYPOR mutant - G141del/E142N | x-ray diffraction | A, B | — | — |
| 4Y7C | Rat cypor mutant - G141DEL/E142N | x-ray diffraction | A, B | — | — |
| 4Y9R | rat CYPOR mutant - G141del | x-ray diffraction | A, B | — | — |
| 4Y9R | Rat cypor mutant - G141DEL | x-ray diffraction | A, B | — | — |
| 4Y9U | rat CYPOR mutant - G143del | x-ray diffraction | A, B | — | — |
| 4Y9U | Rat cypor mutant - G143DEL | x-ray diffraction | A, B | — | — |
| 4YAF | rat CYPOR with 2'-AMP | x-ray diffraction | A, B | FMN, FAD, 2AM, PO4 | 15 (best 0.81) |
| 4YAF | Rat cypor with 2'-AMP | x-ray diffraction | A, B | — | — |
| 4YAL | Reduced CYPOR with 2'-AMP | x-ray diffraction | A, B | — | — |
| 4YAL | Reduced cypor with 2'-AMP | x-ray diffraction | A, B | — | — |
| 4YAO | Reduced CYPOR mutant - G143del | x-ray diffraction | A, B | FMN, FAD, 2AM, PO4 | 13 (best 0.79) |
| 4YAO | Reduced cypor mutant - G143DEL | x-ray diffraction | A, B | — | — |
| 4YAU | Reduced CYPOR mutant - G141del/E142N | x-ray diffraction | A, B | FMN, FAD, 2AM, PO4 | 10 (best 0.83) |
| 4YAU | Reduced cypor mutant - G141DEL/E142N | x-ray diffraction | A, B | — | — |
| 4YAW | Reduced CYPOR mutant - G141del | x-ray diffraction | A, B | — | — |
| 4YAW | Reduced cypor mutant - G141DEL | x-ray diffraction | A, B | — | — |
| 5URD | Wild type rat cypor bound with NADP+ - oxidized form | x-ray diffraction | A, B | FMN, FAD, NAP, PO4 | — |
| 5URE | Wild type rat CYPOR bound with NADP+ - reduced form | x-ray diffraction | A, B | FMN, FAD, NAP, PO4 | — |
| 5URE | Wild type rat cypor bound with NADP+ - reduced form | x-ray diffraction | A, B | FMN, FAD, NAP, PO4 | — |
| 5URG | Rat cypor D632F mutant | x-ray diffraction | A, B | FMN, FAD, NAP, PO4 | — |
| 5URH | CYPOR/D632A with NADP+ | x-ray diffraction | A, B | FMN, FAD, NAP, PO4 | — |
| 5URI | Rat CYPOR/D632A with 2'-AMP | x-ray diffraction | A, B | FMN, FAD, 2AM, PO4 | 12 (best 0.80) |
| 5URI | Rat CYPOR/D632A with 2'-AMP | x-ray diffraction | A, B | FMN, FAD, 2AM, PO4 | — |
| 6J79 | Fusion protein of heme oxygenase-1 and NADPH-cytochrome P450 reductase (13aa) | x-ray diffraction | A, B | FAD, FMN, HEM | — |
| 6J79 | Fusion protein of heme oxygenase-1 and NADPH-cytochrome P450 reductase (13AA) | x-ray diffraction | A, B | FAD, FMN, HEM | — |
| 6J7A | Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (17AA) | x-ray diffraction | A, B | HEM, FAD, FMN | — |
| 6J7I | Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (15aa) | x-ray diffraction | A, B | HEM, FAD, FMN | 18 (best 0.80) |
| 6J7I | Fusion protein of heme oxygenase-1 and NADPH cytochrome P450 reductase (15AA) | x-ray diffraction | A, B | HEM, FAD, FMN | — |
| 6NJR | Spin-Labeled T177C/A637C Mutant of Rat CYPOR | x-ray diffraction | A, B | FMN, FAD, NAP | 14 (best 0.82) |
| 6NJR | Spin-labeled T177C/A637C mutant of rat cypor | x-ray diffraction | A, B | FMN, FAD, NAP | — |
| 7L18 | Crystal structure of a tandem deletion mutant of rat NADPH-cytochrome P450 reductase | x-ray diffraction | AAA, BBB | FMN, FAD, NAP | 11 (best 0.82) |
| P00388 | AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388) | predicted | A | — | 5 (best 0.84) |
Ligands
Experiment against prediction
- 4YAF chain A against the predicted model P00388: TM-score 1.00, RMSD 0.39 Å
- 4YAF chain A against the predicted model P00388: TM-score 1.00, RMSD 0.39 Å
- 4YAW chain A against the predicted model P00388: TM-score 1.00, RMSD 0.41 Å
- 4YAW chain A against the predicted model P00388: TM-score 1.00, RMSD 0.41 Å
- 5URH chain A against the predicted model P00388: TM-score 1.00, RMSD 0.42 Å
- 4Y7C chain A against the predicted model P00388: TM-score 1.00, RMSD 0.42 Å
- 4Y7C chain A against the predicted model P00388: TM-score 1.00, RMSD 0.42 Å
- 4YAU chain A against the predicted model P00388: TM-score 1.00, RMSD 0.43 Å
- 4YAU chain A against the predicted model P00388: TM-score 1.00, RMSD 0.43 Å
- 4Y9R chain A against the predicted model P00388: TM-score 1.00, RMSD 0.43 Å
Elsewhere
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