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Crystal structure of the compound 34 in a complex with TRF2

Analyse Crystal structure of the compound 34 in a complex with TRF2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6J67
Type: protein
Length: 209 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Telomeric repeat-binding factor 2; 3FB-phe-B8R-leu-5XU-pro
UniProt: Q15554
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Telomeric repeat-binding factor 2	protein	203	71% helix, 0% strand	Q15554
C	3FB-phe-B8R-leu-5XU-pro	protein	6	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.47	0.79	19	empty

Interfaces

1 interface between chains.

A–C · 624 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (nonstandard).

Compared structures

6J67 · Crystal structure of the compound 34 in a complex with TRF2 · the same entry in another collection · chain A against A, TM-score 1.00
Q15554 · AlphaFold monomer V2.0 prediction for telomeric repeat-binding factor 2 (Q15554) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15554
Elsewhere: RCSB PDB 6J67 · PDBe 6J67 · UniProt Q15554

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