Research workbench

WWP2 semi-open conformation

Analyse WWP2 semi-open conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6J1Z
Type: protein
Length: 403 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NEDD4-like E3 ubiquitin-protein ligase WWP2
EC: 2.3.2.26
UniProt: O00308
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26)	protein	403	51% helix, 12% strand	O00308

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	945	0.75	0.78	109	empty
2	137	0.71	0.91	24	empty
3	58	0.36	0.78	18	empty
4	50	0.35	0.80	16	empty
5	61	0.29	0.74	15	empty

Compared structures

6J1Z · WWP2 semi-open conformation · the same entry in another collection · chain A against A, TM-score 1.00
O00308 · AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00308
Elsewhere: RCSB PDB 6J1Z · PDBe 6J1Z · UniProt O00308

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