Research workbench
Crystal structure of the cysr-CTLD2 fragment of human mr at acidic pH (pH 4.6)
Analyse Crystal structure of the cysr-CTLD2 fragment of human mr at acidic pH (pH 4.6) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6INO
- Type
- protein
- Length
- 893 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage mannose receptor 1
- UniProt
- P22897
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage mannose receptor 1 | protein | 445 | 14% helix, 34% strand | P22897 |
| B | Macrophage mannose receptor 1 | protein | 448 | 14% helix, 34% strand | P22897 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 891 | 0.76 | 0.79 | 78 | empty |
| 2 | 73 | 0.39 | 0.79 | 13 | empty |
| 3 | 52 | 0.38 | 0.81 | 14 | empty |
| 4 | 65 | 0.34 | 0.77 | 18 | empty |
| 5 | 52 | 0.31 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 509 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 6INO · Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH (pH 4.6) · the same entry in another collection · chain A against A, TM-score 1.00
- P22897 · AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22897
- Elsewhere: RCSB PDB 6INO · PDBe 6INO · UniProt P22897
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