Research workbench
Crystal structure of the cysr-CTLD3 fragment of human mr at acidic pH (pH 5.6)
Analyse Crystal structure of the cysr-CTLD3 fragment of human mr at acidic pH (pH 5.6) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6INN
- Type
- protein
- Length
- 2,385 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage mannose receptor 1
- UniProt
- P22897
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 14% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage mannose receptor 1 | protein | 598 | 14% helix, 32% strand | P22897 |
| B | Macrophage mannose receptor 1 | protein | 596 | 14% helix, 33% strand | P22897 |
| C | Macrophage mannose receptor 1 | protein | 596 | 14% helix, 33% strand | P22897 |
| D | Macrophage mannose receptor 1 | protein | 595 | 14% helix, 33% strand | P22897 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 551 | 0.80 | 0.86 | 81 | empty |
| 2 | 1142 | 0.77 | 0.79 | 108 | empty |
| 3 | 1170 | 0.76 | 0.78 | 102 | empty |
| 4 | 1187 | 0.75 | 0.78 | 114 | empty |
| 5 | 659 | 0.73 | 0.80 | 60 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1002 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 901 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 270 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 269 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 264 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 52 disulfide, 36 modified (disulfide, engineered).
Compared structures
- 6INN · Crystal structure of the CysR-CTLD3 fragment of human MR at acidic pH (pH 5.6) · the same entry in another collection · chain D against D, TM-score 1.00
- P22897 · AlphaFold monomer V2.0 prediction for macrophage mannose receptor 1 (P22897) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22897
- Elsewhere: RCSB PDB 6INN · PDBe 6INN · UniProt P22897
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.