Structure of human D-glucuronyl C5 epimerase in complex with product

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 29% strand (DSSP).

Ligands and binding sites

• IDR · alpha-L-idopyranuronic acid · ligand · 8 copies · chains A, B
• GNS · 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose · ligand · 7 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A, B
• MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A, B
• BMA · beta-D-mannopyranose · sugar · 4 copies · chains A, B
• CA · Calcium ion · metal · 2 copies · chains A, B
• GOL · Glycerol · additive · 11 copies · chains A, B
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
• P6G · Hexaethylene glycol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 3327 Ų buried · 42 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 glycan (N-glycosylation).

Compared structures

• 6I02 · Structure of human D-glucuronyl C5 epimerase in complex with product · the same entry in another collection · chain A against A, TM-score 1.00
• O94923 · AlphaFold monomer V2.0 prediction for D-glucuronyl C5-epimerase (O94923) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O94923
• Elsewhere: RCSB PDB 6I02 · PDBe 6I02 · UniProt O94923