UniProt O94923
D-glucuronyl C5-epimerase (O94923)
D-glucuronyl C5-epimerase (UniProt O94923), EC 5.1.3.17: 6 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O94923
- Protein
- D-glucuronyl C5-epimerase
- EC
- 5.1.3.17
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 18 · 2 records with a druggable one
Structures
7 records of O94923 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HZZ | Structure of human D-glucuronyl C5 epimerase | x-ray diffraction | A, B | NAG, MAN, BMA, SO4, CA, CL | — |
| 6HZZ | Structure of human D-glucuronyl C5 epimerase | x-ray diffraction | A, B | NAG, MAN, BMA, SO4, CA, CL | — |
| 6I01 | Structure of human D-glucuronyl C5 epimerase in complex with substrate | x-ray diffraction | A, B | BDP, GNS, NAG, MAN, BMA, CA | 11 (best 0.79) |
| 6I01 | Structure of human D-glucuronyl C5 epimerase in complex with substrate | x-ray diffraction | A, B | BDP, GNS, NAG, MAN, BMA, CA | — |
| 6I02 | Structure of human D-glucuronyl C5 epimerase in complex with product | x-ray diffraction | A, B | GNS, IDR, NAG, MAN, BMA, CA | 7 (best 0.76) |
| 6I02 | Structure of human D-glucuronyl C5 epimerase in complex with product | x-ray diffraction | A, B | GNS, IDR, NAG, MAN, BMA, CA | — |
| O94923 | AlphaFold monomer V2.0 prediction for D-glucuronyl C5-epimerase (O94923) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 6 records
- CA · Calcium ion · in 6 records
- MAN · alpha-D-mannopyranose · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- GNS · 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose · in 4 records
- BDP · beta-D-glucopyranuronic acid · in 2 records
- CL · Chloride ion · in 2 records
- IDR · alpha-L-idopyranuronic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6I02 chain B against the predicted model O94923: TM-score 1.00, RMSD 0.45 Å
- 6I02 chain B against the predicted model O94923: TM-score 1.00, RMSD 0.45 Å
- 6I01 chain A against the predicted model O94923: TM-score 1.00, RMSD 0.58 Å
- 6I01 chain A against the predicted model O94923: TM-score 1.00, RMSD 0.58 Å
- 6I01 chain B against the predicted model O94923: TM-score 0.99, RMSD 0.61 Å
- 6I01 chain B against the predicted model O94923: TM-score 0.99, RMSD 0.61 Å
- 6I02 chain A against the predicted model O94923: TM-score 0.99, RMSD 0.64 Å
- 6I02 chain A against the predicted model O94923: TM-score 0.99, RMSD 0.64 Å
- 6HZZ chain B against the predicted model O94923: TM-score 0.99, RMSD 0.64 Å
- 6HZZ chain B against the predicted model O94923: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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