Research workbench
Solution structure of the human GRB7-SH2 domain in complex with a 10 amino acid peptide PY1139
Analyse Solution structure of the human GRB7-SH2 domain in complex with a 10 amino acid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MW4
- Type
- protein
- Length
- 130 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth factor receptor-bound protein 7; Receptor protein-tyrosine kinase erbb-2
- EC
- 2.7.10.1
- UniProt
- Q14451, P04626
- Pockets
- 3 · best druggability 0.61
Structure
solution nmr · 2 distinct chains · 13% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth factor receptor-bound protein 7 | protein | 120 | 14% helix, 16% strand | Q14451 |
| B | Receptor protein-tyrosine kinase erbb-2 (EC 2.7.10.1) | protein | 10 | 0% helix, 0% strand | P04626 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.61 | 0.92 | 16 | empty |
| 2 | 51 | 0.30 | 0.75 | 11 | empty |
| 3 | 57 | 0.29 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 500 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 1MW4 · Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14451 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 7 (Q14451) · a predicted model of the same protein · chain A against A, TM-score 0.59
- P04626 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-2 (P04626) · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14451
- Every structure of UniProt P04626
- Elsewhere: RCSB PDB 1MW4 · PDBe 1MW4 · UniProt Q14451 · UniProt P04626
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