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Structure of VPS34 lir motif bound to gabarap

Analyse Structure of VPS34 lir motif bound to gabarap in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6HOG
Type
protein
Length
123 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Phosphatidylinositol 3-kinase catalytic subunit type 3, gamma-aminobutyric acid…
EC
2.7.1.137
UniProt
Q8NEB9, O95166
Ligands
SO4

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 21% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APhosphatidylinositol 3-kinase catalytic subunit type 3, gamma-aminobutyric acid receptor-associated protein (EC 2.7.1.137)protein12332% helix, 21% strandQ8NEB9, O95166

Ligands and binding sites

  • SO4 · Sulfate ion · ion · 2 copies · chains A
  • EDO · 1,2-ethanediol · additive · 2 copies · chains A
  • GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6HOG · Structure of VPS34 LIR motif bound to GABARAP · the same entry in another collection · chain A against A, TM-score 1.00
  • O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.90
  • Q8NEB9 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.37

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