MolNFT v1 · #300410 · protein
AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase catalytic subunit type 3 (Q8NEB9)
Q8NEB9: “AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase catalytic subunit type 3 (Q8NEB9)”. 13 pockets (best druggability 0.68). MolNFT v1 #300410 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8NEB9
- Type
- protein
- Length
- 887 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x05d2f765e98105817e4C261742F64227ab4eA5Ae
- Molecule
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- UniProt
- Q8NEB9
- Pockets
- 13 · best druggability 0.68
Structure
1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3-kinase catalytic subunit type 3 | protein | 887 | 44% helix, 15% strand | Q8NEB9 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 697 | 0.68 | 0.76 | 55 | empty |
| 2 | 256 | 0.60 | 0.79 | 34 | empty |
| 3 | 209 | 0.59 | 0.80 | 23 | empty |
| 4 | 112 | 0.50 | 0.81 | 20 | empty |
| 5 | 111 | 0.44 | 0.78 | 27 | empty |
Compared structures
- 6I3U · Optimization of potent and selective atm inhibitors suitable for a proof-of-concept study… · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6I3U · Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study… · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6YKG · Structure-based exploration of selectivity for ATM inhibitors in Huntingtons disease · an experimental structure of the same protein · chain A against AAA, TM-score 0.61
- 8RXR · Crystal structure of VPS34 in complex with inhibitor SB02024 · an experimental structure of the same protein · chain A against B, TM-score 0.60
- 3IHY · Human PIK3C3 crystal structure · an experimental structure of the same protein · chain A against B, TM-score 0.60
- 3IHY · Human PIK3C3 crystal structure · an experimental structure of the same protein · chain A against B, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NEB9
- Elsewhere: UniProt Q8NEB9 · AlphaFold DB Q8NEB9
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