UniProt O95166
Gamma-aminobutyric acid receptor-associated protein (O95166)
Gamma-aminobutyric acid receptor-associated protein (UniProt O95166), EC 2.7.10.1: 55 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 27 pockets. Binding sites, druggability and experiment against…
- UniProt
- O95166
- Protein
- Gamma-aminobutyric acid receptor-associated protein
- EC
- 2.7.10.1
- Experimental structures
- 55
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 27 · 4 records with a druggable one
Structures
56 records of O95166 in the MolNFT archive: 55 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GNU | GABA(A) receptor associated protein GABARAP | x-ray diffraction | A | — | — |
| 1GNU | GABA(A) receptor associated protein gabarap | x-ray diffraction | A | — | — |
| 1KLV | Solution Structure and Backbone Dynamics of GABARAP, GABAA Receptor associated protein | solution nmr | A | — | — |
| 1KLV | Solution structure and backbone dynamics of gabarap, gabaa receptor associated protein | solution nmr | A | — | — |
| 1KM7 | Solution Structure and Backbone Dynamics of GABARAP, GABAA Receptor Associated Protein | solution nmr | A | — | — |
| 1KM7 | Solution structure and backbone dynamics of gabarap, gabaa receptor associated protein | solution nmr | A | — | — |
| 1KOT | Solution Structure of Human GABA Receptor Associated Protein GABARAP | solution nmr | A | — | — |
| 1KOT | Solution structure of human GABA receptor associated protein gabarap | solution nmr | A | — | — |
| 3D32 | Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide | x-ray diffraction | A, B | — | — |
| 3D32 | Complex of GABA(A) receptor-associated protein (gabarap) with a synthetic peptide | x-ray diffraction | A, B | — | — |
| 3DOW | Complex structure of GABA type A receptor associated protein and its binding epitope on calreticulin | x-ray diffraction | A | — | — |
| 3DOW | Complex structure of GABA type a receptor associated protein and its binding epitope on calreticulin | x-ray diffraction | A | — | — |
| 3WIM | GABARAP-LIR peptide complex | x-ray diffraction | A | — | — |
| 3WIM | Gabarap-lir peptide complex | x-ray diffraction | A | — | — |
| 5DPS | Crystal structure of PLEKHM1 LIR-fused human GABARAP_2-117 | x-ray diffraction | A, B, C | — | — |
| 5DPS | Crystal structure of PLEKHM1 lir-fused human GABARAP_2-117 | x-ray diffraction | A, B, C | — | — |
| 6HB9 | Crystal structure of the GABARAP in complex with the UBA5 LIR motif | x-ray diffraction | A | — | 1 (best 0.39) |
| 6HB9 | Crystal structure of the gabarap in complex with the UBA5 lir motif | x-ray diffraction | A | — | — |
| 6HOG | Structure of VPS34 lir motif bound to gabarap | x-ray diffraction | A | SO4 | — |
| 6HOH | Structure of VPS34 LIR motif (S249E) bound to GABARAP | x-ray diffraction | A, B, C, D | — | — |
| 6HOH | Structure of VPS34 lir motif (S249E) bound to gabarap | x-ray diffraction | A, B, C, D | — | — |
| 6HOJ | Structure of BECLIN1 lir motif bound to gabarap | x-ray diffraction | A, B, C | SO4 | — |
| 6HOK | Structure of Beclin1 LIR (S96E) motif bound to GABARAP | x-ray diffraction | A | — | — |
| 6HOK | Structure of BECLIN1 lir (S96E) motif bound to gabarap | x-ray diffraction | A | — | — |
| 6HYL | Structure of PCM1 lir motif bound to gabarap | x-ray diffraction | A, B | — | — |
| 6HYM | Structure of PCM1 LIR motif bound to GABARAP | x-ray diffraction | A, B | — | — |
| 6HYM | Structure of PCM1 lir motif bound to gabarap | x-ray diffraction | A, B | — | — |
| 6HYN | Structure of ATG13 LIR motif bound to GABARAP | x-ray diffraction | A | — | — |
| 6HYN | Structure of ATG13 lir motif bound to gabarap | x-ray diffraction | A | — | — |
| 6HYO | Structure of ULK1 LIR motif bound to GABARAP | x-ray diffraction | A | — | — |
| 6HYO | Structure of ULK1 lir motif bound to gabarap | x-ray diffraction | A | — | — |
| 6YOP | Structure of SAMM50 LIR bound to GABARAP | x-ray diffraction | A | — | — |
| 6YOP | Structure of SAMM50 lir bound to gabarap | x-ray diffraction | A | — | — |
| 7AA8 | Structure of SCOC LIR bound to GABARAP | x-ray diffraction | C | — | — |
| 7AA8 | Structure of scoc lir bound to gabarap | x-ray diffraction | C | — | — |
| 7BRQ | Crystal structure of human FAM134B LIR fused to human GABARAP | x-ray diffraction | A | — | — |
| 7BRQ | Crystal structure of human FAM134B lir fused to human gabarap | x-ray diffraction | A | — | — |
| 7BRT | Crystal structure of Sec62 LIR fused to GABARAP | x-ray diffraction | A, B | — | 2 (best 0.61) |
| 7BRT | Crystal structure of SEC62 lir fused to gabarap | x-ray diffraction | A, B | — | — |
| 7BRU | Crystal structure of human RTN3 lir fused to human gabarap | x-ray diffraction | A, B, C | PO4 | — |
| 7BV4 | Crystal structure of STX17 lir region in complex with gabarap | x-ray diffraction | A, B, E, G | — | — |
| 7EA7 | Crystal structure of NAP1 lir in complex with gabarap | x-ray diffraction | A, B | — | — |
| 7LSW | Structure of full beta-hairpin lir from FNIP2 bound to gabarap | x-ray diffraction | A, B, C, D, E, F | SO4 | — |
| 7LT6 | Structure of partial beta-hairpin lir from FNIP2 bound to gabarap | x-ray diffraction | A, B, C | — | — |
| 7VEC | Crystal structure of GABARAP complexed with the TEX264 LIR phosphorylated at Ser271 and Ser272 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | 15 (best 0.79) |
| 7VEC | Crystal structure of gabarap complexed with the TEX264 lir phosphorylated at SER271 and SER272 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 7VED | Crystal structure of GABARAP fused to TEX264 LIR with S272D mutation | x-ray diffraction | A, B | SO4 | 1 (best 0.58) |
| 7VED | Crystal structure of gabarap fused to TEX264 lir with S272D mutation | x-ray diffraction | A, B | SO4 | — |
| 7ZKR | Human gabarap in complex with stapled peptide PEN3-ortho | x-ray diffraction | A | PO4, OXE | — |
| 7ZL7 | Human gabarap in complex with stapled peptide PEN8-ortho | x-ray diffraction | A, C | ACE, CL, NA, OXE | — |
| 8S1M | Crystal structure of human GABARAP fused to EGFR (1076-1099) | x-ray diffraction | A | CL | — |
| 8T2M | Crystal structure of GABARAP in complex with the LIR of NSs4 | x-ray diffraction | A | — | — |
| 8T2N | Crystal structure of GABARAP in complex with the LIR of NSs3 | x-ray diffraction | A, C | — | 3 (best 0.49) |
| 8T33 | Crystal structure of K46 acetylated GABARAP in complex with the LIR of TP53INP2/DOR | x-ray diffraction | A | ZN | — |
| 8W6A | Crystal structure of TAX1BP1 LIR region in complex with GABARAP | x-ray diffraction | A, B, D, G | — | 5 (best 0.78) |
| O95166 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein (O95166) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8T33 chain A against the predicted model O95166: TM-score 0.99, RMSD 0.44 Å
- 7LSW chain C against the predicted model O95166: TM-score 0.80, RMSD 0.45 Å
- 8T2M chain A against the predicted model O95166: TM-score 0.90, RMSD 0.46 Å
- 6HYN chain A against the predicted model O95166: TM-score 0.88, RMSD 0.48 Å
- 6HYN chain A against the predicted model O95166: TM-score 0.88, RMSD 0.48 Å
- 8S1M chain A against the predicted model O95166: TM-score 0.84, RMSD 0.50 Å
- 6YOP chain A against the predicted model O95166: TM-score 0.87, RMSD 0.51 Å
- 6YOP chain A against the predicted model O95166: TM-score 0.87, RMSD 0.51 Å
- 7LSW chain D against the predicted model O95166: TM-score 0.80, RMSD 0.50 Å
- 6HYO chain A against the predicted model O95166: TM-score 0.88, RMSD 0.51 Å
Elsewhere
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