Research workbench
Factor inhibiting hif (fih) in complex with zinc, nog and TRPA1 (313- 339)
Analyse Factor inhibiting hif (fih) in complex with zinc, nog and TRPA1 (313- 339) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HC8
- Type
- protein
- Length
- 360 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxia-inducible factor 1-alpha inhibitor; Transient receptor potential cation channel…
- EC
- 1.14.11.30, 1.14.11.-
- UniProt
- Q9NWT6, O75762
- Ligands
- OGA, ZN, SO4
- Pockets
- 5 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30, 1.14.11.-) | protein | 344 | 31% helix, 25% strand | Q9NWT6 |
| E | Transient receptor potential cation channel subfamily a member 1 | protein | 16 | 31% helix, 0% strand | O75762 |
Ligands and binding sites
- OGA · N-oxalylglycine · ligand · chains A
- ZN · Zinc ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.74 | 0.97 | 22 | ZN, OGA |
| 2 | 93 | 0.47 | 0.81 | 24 | GOL |
| 3 | 103 | 0.44 | 0.78 | 20 | empty |
| 4 | 137 | 0.42 | 0.75 | 23 | empty |
| 5 | 56 | 0.35 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–E · 955 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6HC8 · Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NWT6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha inhibitor (Q9NWT6) · a predicted model of the same protein · chain A against A, TM-score 0.94
- O75762 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain E against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWT6
- Every structure of UniProt O75762
- Elsewhere: RCSB PDB 6HC8 · PDBe 6HC8 · UniProt Q9NWT6 · UniProt O75762
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