Research workbench
Factor inhibiting hif (fih) in complex with zinc, nog and TRPV3 (220- 246)
Analyse Factor inhibiting hif (fih) in complex with zinc, nog and TRPV3 (220- 246) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HA6
- Type
- protein
- Length
- 354 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxia-inducible factor 1-alpha inhibitor; Transient receptor potential cation channel…
- EC
- 1.14.11.30, 1.14.11.-
- UniProt
- Q9NWT6, Q8NET8
- Ligands
- OGA, ZN, SO4
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30, 1.14.11.-) | protein | 340 | 31% helix, 25% strand | Q9NWT6 |
| D | Transient receptor potential cation channel subfamily V member 3 | protein | 14 | 29% helix, 0% strand | Q8NET8 |
Ligands and binding sites
- OGA · N-oxalylglycine · ligand · chains A
- ZN · Zinc ion · metal · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A, D
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.76 | 0.98 | 22 | OGA, ZN |
| 2 | 145 | 0.48 | 0.78 | 25 | empty |
| 3 | 103 | 0.45 | 0.79 | 25 | GOL |
| 4 | 104 | 0.39 | 0.75 | 23 | empty |
Interfaces
1 interface between chains.
- A–D · 871 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6HA6 · Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NWT6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha inhibitor (Q9NWT6) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain D against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWT6
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6HA6 · PDBe 6HA6 · UniProt Q9NWT6 · UniProt Q8NET8
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