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Crystal structure of the light-driven proton pump coccomyxa subellipsoidea rhodopsin csr

Analyse Crystal structure of the light-driven proton pump coccomyxa subellipsoidea… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6GYH
Type
protein
Length
225 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Family a G protein-coupled receptor-like protein
UniProt
I0YUS5
Ligands
OLB, RET, CLR
Pockets
1 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 4% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AFamily a G protein-coupled receptor-like proteinprotein22577% helix, 4% strandI0YUS5

Ligands and binding sites

  • OLB · (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · ligand · 4 copies · chains A
  • RET · Retinal · ligand · chains A
  • CLR · Cholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11110.810.9923RET

Modifications

Observed in the structure: 1 cofactor (retinal Schiff base).

Compared structures

  • 6GYH · Crystal structure of the light-driven proton pump Coccomyxa subellipsoidea Rhodopsin CsR · the same entry in another collection · chain A against A, TM-score 1.00

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