High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 8% strand (DSSP).

Ligands and binding sites

• OLA · Oleic acid · ligand · 9 copies · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 6 copies
• BMA · beta-D-mannopyranose · sugar · 3 copies
• FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A, B
• NH2 · Amino group · ion · chains A, B
• CL · Chloride ion · ion · chains A
• ACY · Acetic acid · additive · chains A
• PG4 · Tetraethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 2130 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified, 4 disulfide, 3 glycan (disulfide, nonstandard, N-glycosylation, alkylation).

Compared structures

• 6FJ3 · High resolution crystal structure of parathyroid hormone 1 receptor in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
• Q27IM2 · AlphaFold monomer V2.0 prediction for parathyroid hormone (Q27IM2) · a predicted model of the same protein · chain B against A, TM-score 0.87
• Q03431 · AlphaFold monomer V2.0 prediction for parathyroid HORMONE/PARATHYROID hormone-related… · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q03431
• Every structure of UniProt Q9V2J8
• Every structure of UniProt Q27IM2
• Elsewhere: RCSB PDB 6FJ3 · PDBe 6FJ3 · UniProt Q03431 · UniProt Q9V2J8 · UniProt Q27IM2