Research workbench
Crystal structure of MGLUR5 in complex with mmpep at 2.2 a
Analyse Crystal structure of MGLUR5 in complex with mmpep at 2.2 a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FFI
- Type
- protein
- Length
- 410 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 5,ENDOLYSIN,METABOTROPIC glutamate receptor 5
- EC
- 3.2.1.17
- UniProt
- P41594, P00720
- Ligands
- OLA, D8B
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 5,ENDOLYSIN,METABOTROPIC glutamate receptor 5 (EC 3.2.1.17) | protein | 410 | 74% helix, 4% strand | P41594, P00720 |
Ligands and binding sites
- OLA · Oleic acid · ligand · 7 copies · chains A
- D8B · 2-[2-(3-methoxyphenyl)ethynyl]-6-methyl-pyridine · ligand · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.78 | 0.89 | 55 | MES, D8B |
| 2 | 489 | 0.69 | 0.80 | 49 | empty |
| 3 | 70 | 0.64 | 0.91 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide, 1 modified (disulfide, alkylation).
Compared structures
- 6FFI · Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A · the same entry in another collection · chain A against A, TM-score 1.00
- P41594 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 5 (P41594) · a predicted model of the same protein · chain A against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41594
- Every structure of UniProt P00720
- Elsewhere: RCSB PDB 6FFI · PDBe 6FFI · UniProt P41594 · UniProt P00720
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