UniProt P41594
Metabotropic glutamate receptor 5 (P41594)
Metabotropic glutamate receptor 5 (UniProt P41594), EC 3.2.1.17: 28 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 177 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P41594
- Protein
- Metabotropic glutamate receptor 5
- EC
- 3.2.1.17
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 177 · 10 records with a druggable one
Structures
29 records of P41594 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LMK | Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate | x-ray diffraction | A, B | — | — |
| 3LMK | Ligand binding domain of metabotropoc glutamate receptor MGLUR5 complexed with glutamate | x-ray diffraction | A, B | — | — |
| 4OO9 | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | — | — |
| 4OO9 | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | — | — |
| 5CGC | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | OLA, 51D | — |
| 5CGC | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | — | — |
| 5CGD | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | OLA, 51E | — |
| 5CGD | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in… | x-ray diffraction | A | — | — |
| 6FFH | Crystal structure of MGLUR5 in complex with fenobam at 2.65 a | x-ray diffraction | A | OLA, D7W | — |
| 6FFI | Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A | x-ray diffraction | A | OLA, D8B | 3 (best 0.78) |
| 6FFI | Crystal structure of MGLUR5 in complex with mmpep at 2.2 a | x-ray diffraction | A | OLA, D8B | — |
| 6N4X | Metabotropic glutamate receptor 5 apo form ligand binding domain | x-ray diffraction | A, B | NAG, MG | — |
| 6N4Y | Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 | x-ray diffraction | A, B, C, D | NAG, FUC, BMA, MAN | 20 (best 0.69) |
| 6N4Y | Metabotropic glutamate receptor 5 extracellular domain with NB43 | x-ray diffraction | A, B, C, D | NAG, FUC, BMA, MAN | — |
| 6N50 | Metabotropic glutamate receptor 5 extracellular domain in complex with NB43 and L-quisqualic acid | x-ray diffraction | A, B, C | NAG, QUS | — |
| 6N51 | Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43 | electron microscopy | B, A | NAG, QUS | 20 (best 0.86) |
| 6N51 | Metabotropic glutamate receptor 5 bound to L-quisqualate and NB43 | electron microscopy | B, A | NAG, QUS | — |
| 6N52 | Metabotropic glutamate receptor 5 apo form | electron microscopy | A, B | NAG | — |
| 7FD8 | Thermostabilised full length human mGluR5-5M bound with L-quisqualic acid | electron microscopy | A, B | NAG, QUS, Y01 | 19 (best 0.84) |
| 7FD8 | Thermostabilised full length human MGLUR5-5M bound with L-quisqualic acid | electron microscopy | A, B | NAG, QUS, Y01 | — |
| 7FD9 | Thermostabilised full length human MGLUR5-5M with orthosteric antagonist, LY341495 | electron microscopy | A, B | NAG, Z99 | — |
| 7P2L | Thermostabilised 7TM domain of human MGLU5 receptor bound to photoswitchable ligand alloswitch-1 | x-ray diffraction | A | 4YI | — |
| 8T6J | CDPPB-bound inactive mGlu5 | electron microscopy | B, A | YKU | 16 (best 0.82) |
| 8T8M | Quis-bound intermediate mGlu5 | electron microscopy | A, B | QUS | 20 (best 0.86) |
| 8TAO | Quis and CDPPB bound active mGlu5 | electron microscopy | A, B | QUS, YKU | 20 (best 0.84) |
| 8X0B | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with Quisqualate and VU0424465 | electron microscopy | A, B | NAG, QUS, XQT | 19 (best 0.81) |
| 8X0C | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and VU0424465, conformer 1 | electron microscopy | A, B | NAG, QUS, XQT | 20 (best 0.81) |
| 8X0D | Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate and VU0424465, conformer 2 | electron microscopy | A, B | NAG, QUS, XQT | 20 (best 0.82) |
| P41594 | AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 5 (P41594) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 13 records
- QUS · (S)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid · in 10 records
- OLA · Oleic acid · in 5 records
- XQT · Vu0424465 · in 3 records
- BMA · beta-D-mannopyranose · in 2 records
- D8B · 2-[2-(3-methoxyphenyl)ethynyl]-6-methyl-pyridine · in 2 records
- FUC · alpha-L-fucopyranose · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- YKU · 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide · in 2 records
- 4YI · 2-chloranyl-~{N}-[2-methoxy-4-[(~{E})-pyridin-2-yldiazenyl]phenyl]benzamide · in 1 record
- 51D · 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile · in 1 record
- 51E · 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile · in 1 record
- D7W · 1-(3-chlorophenyl)-3-(3-methyl-5-oxidanylidene-4~{H}-imidazol-2-yl)urea · in 1 record
- MG · Magnesium ion · in 1 record
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · in 1 record
Experiment against prediction
- 8X0B chain B against the predicted model P41594: TM-score 0.96, RMSD 2.03 Å
- 8X0C chain B against the predicted model P41594: TM-score 0.96, RMSD 2.03 Å
- 3LMK chain B against the predicted model P41594: TM-score 0.96, RMSD 1.58 Å
- 3LMK chain B against the predicted model P41594: TM-score 0.96, RMSD 1.58 Å
- 6N50 chain B against the predicted model P41594: TM-score 0.95, RMSD 1.76 Å
- 8X0D chain A against the predicted model P41594: TM-score 0.95, RMSD 2.29 Å
- 6N50 chain A against the predicted model P41594: TM-score 0.95, RMSD 1.91 Å
- 3LMK chain A against the predicted model P41594: TM-score 0.95, RMSD 1.80 Å
- 3LMK chain A against the predicted model P41594: TM-score 0.95, RMSD 1.80 Å
- 8T8M chain A against the predicted model P41594: TM-score 0.94, RMSD 2.47 Å
Elsewhere
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