Research workbench
Dynein light intermediate chain region of the dynein TAIL/DYNACTIN/BICDR1 complex
Analyse Dynein light intermediate chain region of the dynein TAIL/DYNACTIN/BICDR1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6F1Y
- Type
- protein
- Length
- 583 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytoplasmic dynein 1 heavy chain 1,DYNEIN heavy chain; Cytoplasmic dynein 1 light…
- UniProt
- Q14204, O43237
- Pockets
- 7 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 55% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| f | Cytoplasmic dynein 1 heavy chain 1,DYNEIN heavy chain | protein | 280 | 77% helix, 0% strand | Q14204 |
| j | Cytoplasmic dynein 1 light intermediate chain 2 | protein | 303 | 35% helix, 11% strand | O43237 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.80 | 0.83 | 91 | empty |
| 2 | 217 | 0.73 | 0.88 | 35 | empty |
| 3 | 103 | 0.72 | 0.93 | 18 | empty |
| 4 | 108 | 0.67 | 0.90 | 28 | empty |
| 5 | 252 | 0.63 | 0.81 | 40 | empty |
Interfaces
1 interface between chains.
- f–j · 1346 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6F1Y · Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex · the same entry in another collection · chain f against f, TM-score 1.00
- O43237 · AlphaFold monomer V2.0 prediction for cytoplasmic dynein 1 light intermediate chain 2… · a predicted model of the same protein · chain j against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14204
- Every structure of UniProt O43237
- Elsewhere: RCSB PDB 6F1Y · PDBe 6F1Y · UniProt Q14204 · UniProt O43237
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.