UniProt O43237
Cytoplasmic dynein 1 light intermediate chain 2 (O43237)
Cytoplasmic dynein 1 light intermediate chain 2 (UniProt O43237): 19 experimental structures and 1 predicted model on GenesisL1, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43237
- Protein
- Cytoplasmic dynein 1 light intermediate chain 2
- Experimental structures
- 19
- Predicted models
- 1
- Pockets
- 28 · 9 records with a druggable one
Structures
20 records of O43237 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6F1T | Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 | electron microscopy | i, j, q, r | — | 6 (best 0.85) |
| 6F1T | Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 | electron microscopy | i, j, q, r | — | — |
| 6F1Y | Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex | electron microscopy | j | — | — |
| 6F1Y | Dynein light intermediate chain region of the dynein TAIL/DYNACTIN/BICDR1 complex | electron microscopy | j | — | — |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | i, j, q, r | — | 1 (best 0.80) |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | i, j, q, r | — | — |
| 6F3A | Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N | electron microscopy | j | — | — |
| 7Z8F | Composite structure of dynein-dynactin-BICDR on microtubules | electron microscopy | i, j, q, r | — | — |
| 7Z8I | The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2) | electron microscopy | j, r | — | — |
| 7Z8J | Cytoplasmic dynein (A2) bound to BICDR1 | electron microscopy | j, r | — | 5 (best 0.74) |
| 7Z8J | Cytoplasmic dynein (A2) bound to BICDR1 | electron microscopy | j, r | — | — |
| 7Z8K | Cytoplasmic dynein (A1) bound to BICDR1 | electron microscopy | i | — | 3 (best 0.73) |
| 7Z8K | Cytoplasmic dynein (A1) bound to BICDR1 | electron microscopy | i | — | — |
| 7Z8L | Cytoplasmic dynein light intermediate chain (B1) bound to the motor domain (A2). | electron microscopy | q | — | 2 (best 0.80) |
| 7Z8L | Cytoplasmic dynein light intermediate chain (B1) bound to the motor domain (A2). | electron microscopy | q | — | — |
| 8PR0 | Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower | electron microscopy | K | — | 3 (best 0.79) |
| 8PR2 | Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI | electron microscopy | j | — | 2 (best 0.52) |
| 8PR3 | Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1 | electron microscopy | j, E, F | — | 5 (best 0.70) |
| 8PTK | Composite structure of Dynein-Dynactin-JIP3-LIS1 | electron microscopy | j, q, r, u | — | 1 (best 0.80) |
| O43237 | AlphaFold monomer V2.0 prediction for cytoplasmic dynein 1 light intermediate chain 2 (O43237) | predicted | A | — | — |
Experiment against prediction
- 7Z8L chain q against the predicted model O43237: TM-score 0.96, RMSD 1.19 Å
- 7Z8L chain q against the predicted model O43237: TM-score 0.96, RMSD 1.19 Å
- 8PR3 chain j against the predicted model O43237: TM-score 0.91, RMSD 1.98 Å
- 7Z8F chain r against the predicted model O43237: TM-score 0.91, RMSD 2.01 Å
- 7Z8F chain i against the predicted model O43237: TM-score 0.90, RMSD 2.06 Å
- 7Z8K chain i against the predicted model O43237: TM-score 0.90, RMSD 2.20 Å
- 7Z8K chain i against the predicted model O43237: TM-score 0.90, RMSD 2.20 Å
- 8PTK chain q against the predicted model O43237: TM-score 0.90, RMSD 2.34 Å
- 7Z8J chain r against the predicted model O43237: TM-score 0.88, RMSD 0.19 Å
- 7Z8J chain r against the predicted model O43237: TM-score 0.88, RMSD 0.19 Å
Elsewhere
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