Research workbench
Human huntingtin-HAP40 complex structure
Analyse Human huntingtin-HAP40 complex structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EZ8
- Type
- protein
- Length
- 2,621 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Huntingtin; Factor VIII intron 22 protein
- UniProt
- P42858, P23610
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 2 distinct chains · 46% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Huntingtin | protein | 2353 | 47% helix, 0% strand | P42858 |
| B | Factor VIII intron 22 protein | protein | 268 | 42% helix, 0% strand | P23610 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 818 | 0.90 | 0.93 | 132 | empty |
| 2 | 1191 | 0.84 | 0.85 | 122 | empty |
| 3 | 132 | 0.79 | 0.96 | 30 | empty |
| 4 | 135 | 0.78 | 0.96 | 46 | empty |
| 5 | 264 | 0.78 | 0.91 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 5656 Ų buried · 40 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42858
- Every structure of UniProt P23610
- Elsewhere: RCSB PDB 6EZ8 · PDBe 6EZ8 · UniProt P42858 · UniProt P23610
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