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Crystal structure of the human WNK2 CCT1 domain

Analyse Crystal structure of the human WNK2 CCT1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ELM
Type: protein
Length: 98 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase WNK2
EC: 2.7.11.1
UniProt: Q9Y3S1
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase WNK2 (EC 2.7.11.1)	protein	98	38% helix, 19% strand	Q9Y3S1

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.34	0.76	16	empty
2	56	0.33	0.78	15	empty

Compared structures

6ELM · Crystal structure of the human WNK2 CCT1 domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y3S1 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK2 (Q9Y3S1) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y3S1
Elsewhere: RCSB PDB 6ELM · PDBe 6ELM · UniProt Q9Y3S1

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