MolNFT v1 · #499955 · protein

AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK2 (Q9Y3S1)

Q9Y3S1: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK2 (Q9Y3S1)”. 5 pockets (best druggability 0.77). MolNFT v1 #499955 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9Y3S1
Type: protein
Length: 2,297 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x917B68ac5F3261871D3Df8D41b8Dd121B8830247
Molecule: SERINE/THREONINE-protein kinase WNK2
UniProt: Q9Y3S1
Pockets: 5 · best druggability 0.77

Structure

1 distinct chain · 10% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase WNK2	protein	2297	10% helix, 4% strand	Q9Y3S1

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	809	0.77	0.80	86	empty
2	224	0.53	0.77	31	empty
3	152	0.45	0.76	21	empty
4	95	0.39	0.77	13	empty
5	85	0.36	0.75	14	empty

Compared structures

6ELM · Crystal structure of the human WNK2 CCT1 domain · an experimental structure of the same protein · chain A against A, TM-score 0.04
6FBK · Crystal structure of the human WNK2 cct-like 1 domain in complex with a WNK1 rfxv peptide · an experimental structure of the same protein · chain A against A, TM-score 0.04

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y3S1
Elsewhere: UniProt Q9Y3S1 · AlphaFold DB Q9Y3S1

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