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A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

Analyse A conserved structural element in the RNA helicase UPF1 regulates its catalytic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6EJ5
Type: protein
Length: 599 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulator of nonsense transcripts 1
EC: 3.6.4.-
UniProt: Q92900
Pockets: 5 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulator of nonsense transcripts 1 (EC 3.6.4.-)	protein	599	33% helix, 18% strand	Q92900

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1159	0.80	0.81	111	empty
2	57	0.45	0.83	19	empty
3	71	0.45	0.81	20	empty
4	58	0.31	0.76	15	empty
5	62	0.31	0.75	17	empty

Compared structures

6EJ5 · A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity… · the same entry in another collection · chain A against A, TM-score 1.00
Q92900 · AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 1 (Q92900) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92900
Elsewhere: RCSB PDB 6EJ5 · PDBe 6EJ5 · UniProt Q92900

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