Research workbench
Crystal structure of helicobacter pylori tlpa chemoreceptor ligand binding domain
Analyse Crystal structure of helicobacter pylori tlpa chemoreceptor ligand binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E0A
- Type
- protein
- Length
- 521 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyl-accepting chemotaxis protein tlpa
- UniProt
- A0A1U9IS38
- Ligands
- ZN, CA, CL
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methyl-accepting chemotaxis protein tlpa | protein | 259 | 37% helix, 34% strand | A0A1U9IS38 |
| B | Methyl-accepting chemotaxis protein tlpa | protein | 262 | 38% helix, 31% strand | A0A1U9IS38 |
Ligands and binding sites
- ZN · Zinc ion · metal · 9 copies · chains A, B
- CA · Calcium ion · metal · chains A, B
- CL · Chloride ion · ion · chains A
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.74 | 0.96 | 18 | empty |
| 2 | 64 | 0.73 | 0.97 | 16 | empty |
| 3 | 468 | 0.69 | 0.80 | 64 | ZN |
| 4 | 287 | 0.62 | 0.79 | 31 | empty |
| 5 | 74 | 0.47 | 0.83 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1125 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6E0A · Crystal Structure of Helicobacter pylori TlpA Chemoreceptor Ligand Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1U9IS38
- Elsewhere: RCSB PDB 6E0A · PDBe 6E0A · UniProt A0A1U9IS38
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.