Crystal structure of bifunctional enzyme fold- methylenetetrahydrofolate DEHYDROGENASE/CYCLOHYDROLASE in the complex with methotrexate from campylobacter jejuni

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• GUN · Guanine · ligand · chains A
• K · Potassium ion · metal · chains A
• CL · Chloride ion · ion · 3 copies · chains A, B
• GOL · Glycerol · additive · 5 copies · chains A, B
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A, B
• DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6DEB · Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate… · the same entry in another collection · chain A against A, TM-score 1.00
• Q0PA35 · AlphaFold monomer V2.0 prediction for bifunctional protein fold (Q0PA35) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q0PA35
• Elsewhere: RCSB PDB 6DEB · PDBe 6DEB · UniProt Q0PA35