Research workbench
Tribbles (TRIB1) pseudokinase fused to ccaat-enhancer binding protein (C/EBPALPHA) degron
Analyse Tribbles (TRIB1) pseudokinase fused to ccaat-enhancer binding protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DC0
- Type
- protein
- Length
- 535 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tribbles homolog 1,CCAAT/ENHANCER-binding protein alpha
- UniProt
- Q96RU8, P49715
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tribbles homolog 1,CCAAT/ENHANCER-binding protein alpha | protein | 265 | 39% helix, 19% strand | Q96RU8, P49715 |
| B | Tribbles homolog 1,CCAAT/ENHANCER-binding protein alpha | protein | 270 | 40% helix, 18% strand | Q96RU8, P49715 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.60 | 0.77 | 43 | empty |
| 2 | 180 | 0.46 | 0.75 | 28 | empty |
| 3 | 183 | 0.43 | 0.74 | 31 | empty |
| 4 | 61 | 0.41 | 0.80 | 15 | empty |
| 5 | 53 | 0.36 | 0.80 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2062 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 6DC0 · Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron · the same entry in another collection · chain A against A, TM-score 1.00
- Q96RU8 · AlphaFold monomer V2.0 prediction for tribbles homolog 1 (Q96RU8) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P49715 · AlphaFold monomer V2.0 prediction for CCAAT/ENHANCER-binding protein alpha (P49715) · a predicted model of the same protein · chain B against A, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RU8
- Every structure of UniProt P49715
- Elsewhere: RCSB PDB 6DC0 · PDBe 6DC0 · UniProt Q96RU8 · UniProt P49715
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