UniProt Q96RU8
Tribbles homolog 1,CCAAT/enhancer-binding protein alpha (Q96RU8)
Tribbles homolog 1,CCAAT/enhancer-binding protein alpha (UniProt Q96RU8): 8 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96RU8
- Protein
- Tribbles homolog 1,CCAAT/enhancer-binding protein alpha
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 9 · 1 record with a druggable one
Structures
9 records of Q96RU8 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CEK | Pseudokinase domain of human tribbles homolog 1 | x-ray diffraction | A | — | — |
| 5CEM | Pseudokinase and C-terminal extension of human tribbles homolog 1 | x-ray diffraction | A | — | — |
| 5IGO | WD40 domain of Arabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from Trib1 | x-ray diffraction | U, V, W, X | — | — |
| 5IGO | WD40 domain of arabidopsis thaliana E3 ubiquitin ligase COP1 in complex with peptide from TRIB1 | x-ray diffraction | U, V, W, X | — | — |
| 5IGQ | WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2) bound to peptide from Trib1 | x-ray diffraction | U, V, W, X, Y, Z | — | — |
| 5IGQ | WD40 domain of human E3 ubiquitin ligase COP1 (RFWD2) bound to peptide from TRIB1 | x-ray diffraction | U, V, W, X, Y, Z | — | — |
| 6DC0 | Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron | x-ray diffraction | A, B | — | 6 (best 0.60) |
| 6DC0 | Tribbles (TRIB1) pseudokinase fused to ccaat-enhancer binding protein (C/EBPALPHA) degron | x-ray diffraction | A, B | — | — |
| Q96RU8 | AlphaFold monomer V2.0 prediction for tribbles homolog 1 (Q96RU8) | predicted | A | — | 3 (best 0.49) |
Experiment against prediction
- 6DC0 chain A against the predicted model Q96RU8: TM-score 0.94, RMSD 0.83 Å
- 6DC0 chain A against the predicted model Q96RU8: TM-score 0.94, RMSD 0.83 Å
- 6DC0 chain B against the predicted model Q96RU8: TM-score 0.92, RMSD 1.36 Å
- 6DC0 chain B against the predicted model Q96RU8: TM-score 0.92, RMSD 1.36 Å
- 5CEK chain A against the predicted model Q96RU8: TM-score 0.91, RMSD 1.89 Å
- 5CEM chain A against the predicted model Q96RU8: TM-score 0.89, RMSD 2.19 Å
- 5IGO chain U against the predicted model Q96RU8: TM-score 0.57, RMSD 0.75 Å
- 5IGO chain U against the predicted model Q96RU8: TM-score 0.57, RMSD 0.75 Å
- 5IGQ chain V against the predicted model Q96RU8: TM-score 0.54, RMSD 0.79 Å
- 5IGQ chain V against the predicted model Q96RU8: TM-score 0.54, RMSD 0.79 Å
Elsewhere
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