Research workbench
Protease sfti complex
Analyse Protease sfti complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6D3Z
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen; Trypsin inhibitor 1
- EC
- 3.4.21.7
- UniProt
- P00747, Q4GWU5
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasminogen (EC 3.4.21.7) | protein | 245 | 10% helix, 36% strand | P00747 |
| C | Trypsin inhibitor 1 | protein | 14 | 0% helix, 36% strand | Q4GWU5 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.32 | 0.74 | 16 | empty |
| 2 | 59 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 651 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 6D3Z · Protease SFTI complex · the same entry in another collection · chain A against A, TM-score 1.00
- P00747 · AlphaFold monomer V2.0 prediction for plasminogen (P00747) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q4GWU5 · AlphaFold monomer V2.0 prediction for trypsin inhibitor 1 (Q4GWU5) · a predicted model of the same protein · chain C against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00747
- Every structure of UniProt Q4GWU5
- Elsewhere: RCSB PDB 6D3Z · PDBe 6D3Z · UniProt P00747 · UniProt Q4GWU5
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