UniProt Q4GWU5
Trypsin inhibitor 1 (Q4GWU5)
Trypsin inhibitor 1 (UniProt Q4GWU5): 39 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4GWU5
- Protein
- Trypsin inhibitor 1
- Experimental structures
- 39
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
40 records of Q4GWU5 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JBL | Solution structure of SFTI-1, A cyclic trypsin inhibitor from sunflower seeds | solution nmr | A | — | — |
| 1JBL | Solution structure of sfti-1, a cyclic trypsin inhibitor from sunflower seeds | solution nmr | A | — | — |
| 1JBN | Solution structure of an acyclic permutant of SFTI-1, A trypsin inhibitor from sunflower seeds | solution nmr | A | — | — |
| 1JBN | Solution structure of an acyclic permutant of sfti-1, a trypsin inhibitor from sunflower seeds | solution nmr | A | — | — |
| 1SFI | High resolution structure of a potent, cyclic protease inhibitor from sunflower seeds | x-ray diffraction | I | — | — |
| 1T9E | NMR solution structure of a disulfide analogue of the cyclic sunflower trypsin inhibitor SFTI-1 | solution nmr | A | — | — |
| 1T9E | NMR solution structure of a disulfide analogue of the cyclic sunflower trypsin inhibitor sfti-1 | solution nmr | A | — | — |
| 2AB9 | Discovery, structural determination and processing of the precursor protein that produces the… | solution nmr | A | — | — |
| 2AB9 | Discovery, structural determination and processing of the precursor protein that produces the… | solution nmr | A | — | — |
| 3P8F | Crystal Structure of MT-SP1 in complex with SFTI-1 | x-ray diffraction | I | — | — |
| 3P8F | Crystal structure of mt-SP1 in complex with sfti-1 | x-ray diffraction | I | — | — |
| 4ABI | Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14)… | x-ray diffraction | B | — | — |
| 4ABI | Co-complex structure of bovine trypsin with a modified bowman-birk inhibitor (PTA)SFTI-1(1,14)… | x-ray diffraction | B | — | — |
| 4ABJ | Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14)… | x-ray diffraction | B | — | — |
| 4ABJ | Co-complex structure of bovine trypsin with a modified bowman-birk inhibitor (ICA)SFTI-1(1,14)… | x-ray diffraction | B | — | — |
| 4HGC | Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at… | x-ray diffraction | I | — | — |
| 4HGC | Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at… | x-ray diffraction | I | — | — |
| 4K1E | Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified… | x-ray diffraction | B | — | — |
| 4K1E | Atomic resolution crystal structures of kallikrein-related peptidase 4 complexed with a modified… | x-ray diffraction | B | — | — |
| 4K8Y | Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with Sunflower… | x-ray diffraction | B | — | — |
| 4K8Y | Atomic resolution crystal structures of kallikrein-related peptidase 4 complexed with sunflower… | x-ray diffraction | B | — | — |
| 4KEL | Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified… | x-ray diffraction | B | — | — |
| 4KEL | Atomic resolution crystal structure of kallikrein-related peptidase 4 complexed with a modified… | x-ray diffraction | B | — | — |
| 4XOJ | Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1) | x-ray diffraction | B | — | — |
| 4XOJ | Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (sfti-1) | x-ray diffraction | B | — | — |
| 6D3X | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold… | x-ray diffraction | C, D | — | 4 (best 0.83) |
| 6D3X | Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold… | x-ray diffraction | C, D | — | — |
| 6D3Y | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold… | x-ray diffraction | C | — | 1 (best 0.35) |
| 6D3Y | Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold… | x-ray diffraction | C | — | — |
| 6D3Z | Protease SFTI complex | x-ray diffraction | C | — | 2 (best 0.32) |
| 6D3Z | Protease sfti complex | x-ray diffraction | C | — | — |
| 6D40 | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold… | x-ray diffraction | C | — | — |
| 6D40 | Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold… | x-ray diffraction | C | — | — |
| 6U7Q | NMR solution structure of SFTI-R10 | solution nmr | A | — | — |
| 6U7Q | NMR solution structure of sfti-R10 | solution nmr | A | — | — |
| 6U7R | NMR solution structure of SFTI1 based KLK7 protease inhibitor | solution nmr | A | — | — |
| 6U7R | NMR solution structure of SFTI1 based KLK7 protease inhibitor | solution nmr | A | — | — |
| 6U7S | NMR solution structure of SFTI-1 based plasmin inhibitor | solution nmr | A | — | — |
| 6U7S | NMR solution structure of sfti-1 based plasmin inhibitor | solution nmr | A | — | — |
| Q4GWU5 | AlphaFold monomer V2.0 prediction for trypsin inhibitor 1 (Q4GWU5) | predicted | A | — | — |
Experiment against prediction
- 6U7S chain A against the predicted model Q4GWU5: TM-score 0.56, RMSD 1.41 Å
- 6U7S chain A against the predicted model Q4GWU5: TM-score 0.56, RMSD 1.41 Å
- 4HGC chain I against the predicted model Q4GWU5: TM-score 0.54, RMSD 0.56 Å
- 4HGC chain I against the predicted model Q4GWU5: TM-score 0.50, RMSD 0.56 Å
- 6U7R chain A against the predicted model Q4GWU5: TM-score 0.45, RMSD 1.71 Å
- 6U7R chain A against the predicted model Q4GWU5: TM-score 0.45, RMSD 1.71 Å
- 4K8Y chain B against the predicted model Q4GWU5: TM-score 0.44, RMSD 1.08 Å
- 4K8Y chain B against the predicted model Q4GWU5: TM-score 0.44, RMSD 1.08 Å
- 4ABI chain B against the predicted model Q4GWU5: TM-score 0.44, RMSD 0.76 Å
- 4ABI chain B against the predicted model Q4GWU5: TM-score 0.44, RMSD 0.76 Å
Elsewhere
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