UniProt P00747
Plasminogen (P00747)
Plasminogen (UniProt P00747), EC 3.4.21.7: 86 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00747
- Protein
- Plasminogen
- EC
- 3.4.21.7
- Experimental structures
- 86
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 44 · 10 records with a druggable one
Structures
87 records of P00747 in the MolNFT archive: 86 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B2I | Kringle 2 domain of human plasminogen: NMR solution structure of… | solution nmr | A | — | — |
| 1B2I | Kringle 2 domain of human plasminogen: NMR solution structure of… | solution nmr | A | — | — |
| 1BML | Complex of the catalytic domain of human plasmin and streptokinase | x-ray diffraction | A, B | — | — |
| 1BML | Complex of the catalytic domain of human plasmin and streptokinase | x-ray diffraction | A, B | — | — |
| 1BUI | Structure of the ternary microplasmin-staphylokinase-microplasmin complex: a… | x-ray diffraction | A, B | — | — |
| 1BUI | Structure of the ternary microplasmin-staphylokinase-microplasmin complex: a… | x-ray diffraction | A, B | — | — |
| 1CEA | The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with… | x-ray diffraction | A, B | — | — |
| 1CEA | The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with… | x-ray diffraction | A, B | — | — |
| 1CEB | The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with… | x-ray diffraction | A, B | — | — |
| 1CEB | The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with… | x-ray diffraction | A, B | — | — |
| 1DDJ | Crystal structure of human plasminogen catalytic domain | x-ray diffraction | A, B, C, D | — | — |
| 1DDJ | Crystal structure of human plasminogen catalytic domain | x-ray diffraction | A, B, C, D | — | — |
| 1HPJ | Solution NMR structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic… | solution nmr | A | — | — |
| 1HPJ | Solution NMR structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic… | solution nmr | A | — | — |
| 1HPK | Solution NMR structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic… | solution nmr | A | — | — |
| 1HPK | Solution NMR structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic… | solution nmr | A | — | — |
| 1I5K | Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an… | x-ray diffraction | A, B | — | — |
| 1I5K | Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an… | x-ray diffraction | A, B | — | — |
| 1KI0 | The X-ray Structure of Human Angiostatin | x-ray diffraction | A | — | — |
| 1KI0 | The X-ray structure of human angiostatin | x-ray diffraction | A | — | — |
| 1KRN | Structure of kringle 4 at 4C temperature and 1.67 ångströms resolution | x-ray diffraction | A | — | — |
| 1KRN | Structure of kringle 4 at 4C temperature and 1.67 ångströms resolution | x-ray diffraction | A | — | — |
| 1L4D | Crystal structure of microplasminogen-streptokinase alpha domain complex | x-ray diffraction | A | — | — |
| 1L4D | Crystal structure of microplasminogen-streptokinase alpha domain complex | x-ray diffraction | A | — | — |
| 1L4Z | X-ray crystal structure of the complex of microplasminogen with alpha domain of streptokinase in… | x-ray diffraction | A | — | — |
| 1L4Z | X-ray crystal structure of the complex of microplasminogen with alpha domain of streptokinase in… | x-ray diffraction | A | — | — |
| 1PK4 | Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-ångströms resolution | x-ray diffraction | A | — | — |
| 1PK4 | Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-ångströms resolution | x-ray diffraction | A | — | — |
| 1PKR | The structure of recombinant plasminogen kringle 1 and the fibrin binding site | x-ray diffraction | A | — | — |
| 1PKR | The structure of recombinant plasminogen kringle 1 and the fibrin binding site | x-ray diffraction | A | — | — |
| 1PMK | Kringle-kringle interactions in multimer kringle structures | x-ray diffraction | A, B | — | — |
| 1PMK | Kringle-kringle interactions in multimer kringle structures | x-ray diffraction | A, B | — | — |
| 1QRZ | Catalytic domain of plasminogen | x-ray diffraction | A, B, C, D | — | — |
| 1QRZ | Catalytic domain of plasminogen | x-ray diffraction | A, B, C, D | — | — |
| 1RJX | Human PLASMINOGEN CATALYTIC DOMAIN, K698M MUTANT | x-ray diffraction | B | — | — |
| 1RJX | Human plasminogen catalytic domain, K698M mutant | x-ray diffraction | B | — | — |
| 2DOH | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a… | x-ray diffraction | X | — | — |
| 2DOH | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a… | x-ray diffraction | X | — | — |
| 2DOI | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide… | x-ray diffraction | X, A | — | — |
| 2DOI | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide… | x-ray diffraction | X, A | — | — |
| 2KNF | Solution structure and functional characterization of human plasminogen kringle 5 | solution nmr | A | — | — |
| 2KNF | Solution structure and functional characterization of human plasminogen kringle 5 | solution nmr | A | — | — |
| 2L0S | Solution Structure of Human Plasminogen Kringle 3 | solution nmr | A | — | — |
| 2L0S | Solution structure of human plasminogen kringle 3 | solution nmr | A | — | — |
| 2PK4 | The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle | x-ray diffraction | A | — | — |
| 2PK4 | The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle | x-ray diffraction | A | — | — |
| 3UIR | Crystal structure of the plasmin-textilinin-1 complex | x-ray diffraction | A, B | — | — |
| 3UIR | Crystal structure of the plasmin-textilinin-1 complex | x-ray diffraction | A, B | — | — |
| 4A5T | Structural basis for the conformational modulation | x-ray diffraction | S | — | — |
| 4A5T | Structural basis for the conformational modulation | x-ray diffraction | S | — | — |
| 4CIK | plasminogen kringle 1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4CIK | Plasminogen kringle 1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4DCB | Y. pestis Plasminogen Activator Pla in Complex with Human Plasminogen Activation Loop Peptide ALP11 | x-ray diffraction | F | — | — |
| 4DUR | The X-ray Crystal Structure of Full-Length type II Human Plasminogen | x-ray diffraction | A, B | — | — |
| 4DUR | The X-ray crystal structure of full-length type II human plasminogen | x-ray diffraction | A, B | — | — |
| 4DUU | The X-ray Crystal Structure of Full-Length type I Human Plasminogen | x-ray diffraction | A | — | — |
| 4DUU | The X-ray crystal structure of full-length type I human plasminogen | x-ray diffraction | A | — | — |
| 5HPG | Structure and ligand determinants of the recombinant kringle 5 domain of human plasminogen | x-ray diffraction | A, B | — | — |
| 5HPG | Structure and ligand determinants of the recombinant kringle 5 domain of human plasminogen | x-ray diffraction | A, B | — | — |
| 5UGD | Protease Inhibitor | x-ray diffraction | A | — | — |
27 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 10 records
- NA · Sodium ion · in 2 records
- 89M · Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide · in 1 record
- EUA · (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(benzenesulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide · in 1 record
- GGI · (5S,8R,18S,21R)-N-{[4-(aminomethyl)phenyl]methyl}-21-[(benzenesulfonyl)amino]-3,11,20-trioxo-2,5,8,12,19-pentaazatetracyclo[21.2.2.2~5,8~.2~13,16~]hentriaconta-1(25),13,15,23,26,28-hexaene-18-carboxamide · in 1 record
- I5Q · (2S)-butane-1,2-diol · in 1 record
- I5Y · (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide · in 1 record
- M63 · (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(3-chlorobenzene-1-sulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide · in 1 record
- NZ5 · (2~{R})-butane-1,2-diol · in 1 record
Experiment against prediction
- 6Q1U chain A against the predicted model P00747: TM-score 0.99, RMSD 0.95 Å
- 6Q1U chain A against the predicted model P00747: TM-score 0.99, RMSD 0.95 Å
- 7THS chain A against the predicted model P00747: TM-score 0.99, RMSD 0.96 Å
- 7UAH chain A against the predicted model P00747: TM-score 0.99, RMSD 0.95 Å
- 8F7U chain A against the predicted model P00747: TM-score 0.99, RMSD 0.97 Å
- 6D3X chain A against the predicted model P00747: TM-score 0.99, RMSD 0.97 Å
- 6D3X chain A against the predicted model P00747: TM-score 0.99, RMSD 0.97 Å
- 1CEA chain A against the predicted model P00747: TM-score 0.99, RMSD 0.39 Å
- 1CEA chain A against the predicted model P00747: TM-score 0.99, RMSD 0.39 Å
- 8F7V chain A against the predicted model P00747: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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