Research workbench
Structure of the PTK6 kinase domain bound to a type I inhibitor (3- fluoro-4-{[6-methyl-3-(1H-pyrazol-4-YL)IMIDAZO[1,2-A]PYRAZIN-8- YL]AMINO}PHENYL)(MORPHOLIN-4-YL)METHANONE
Analyse Structure of the PTK6 kinase domain bound to a type I inhibitor (3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CZ3
- Type
- protein
- Length
- 262 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-tyrosine kinase 6
- EC
- 2.7.10.2
- UniProt
- Q13882
- Ligands
- FLJ, K
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine kinase 6 (EC 2.7.10.2) | protein | 262 | 42% helix, 18% strand | Q13882 |
Ligands and binding sites
- FLJ · (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone · ligand · chains A
- K · Potassium ion · metal · 2 copies · chains A
- ACT · Acetate ion · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 276 | 0.69 | 0.84 | 40 | FLJ |
| 2 | 76 | 0.46 | 0.81 | 14 | empty |
| 3 | 70 | 0.31 | 0.74 | 13 | empty |
Compared structures
- 6CZ3 · Structure of the PTK6 kinase domain bound to a type I inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
- Q13882 · AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 6 (Q13882) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13882
- Elsewhere: RCSB PDB 6CZ3 · PDBe 6CZ3 · UniProt Q13882
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.